Registration Dossier
Registration Dossier
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EC number: 246-885-9 | CAS number: 25354-97-6
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to fish, other
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Study period:
- 2021
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: A QSAR model, ECOSAR was used to estimate long-term toxicity to fish.
- Justification for type of information:
- QSAR prediction from reliable model
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- The QSAR model, Ecological Structure Activity Relationships (ECOSAR) Class Program was used to estimate the long-term toxicity to fish. The following measured values were used in the model: log Kow = 6.21, water solubility = 0.07 mg/L and melting point = -9 C.
- Test organisms (species):
- other: fish
- Water media type:
- freshwater
- Duration:
- 30 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.035 mg/L
- Conclusions:
- Using a reliable QSAR model, Ecological Structure Activity Relationships (ECOSAR) Class Program was used to estimate the 30d NOEC for fish to be 0.035 mg/L.
- Executive summary:
A reliable QSAR model (Ecological Structure-Activity Relationship (ECOSAR) version 2.0) was used to predict the chronic aquatic toxicity of 2-hexyldecanoic acid to fish. The 30 day chronic value (the geometric mean of the NOEC and LOEC) was 0.05 mg/L for the neutral organic class. As per REACH Guidance Ch 10, a NOEC can be calculated from the chronic value. Therefore, the calculated NOEC = 0.035 mg/L and will be used in the assessment.
Reference
Description of key information
An experimental long-term fish toxicity test with 2 -hexyldecanoic acid is not available. However, a reliable calculated value from ECOSAR 2.0 is available.
A fish 30 d NOEC of 0.035 mg/L was calculated for the substance.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Dose descriptor:
- NOEC
- Effect concentration:
- 0.035 mg/L
Additional information
A fish 30 d NOEC of 0.035 mg/L was calculated for 2-hexyldecanoic acid using the ECOSAR 2.0 model.
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