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Physical & Chemical properties

Vapour pressure

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vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
according to guideline
EU Method A.4 (Vapour Pressure)
equivalent or similar to guideline
OECD Guideline 104 (Vapour Pressure Curve)
GLP compliance:
yes (incl. QA statement)
Type of method:
effusion method: Knudsen cell
Key result
Test no.:
20 °C
Vapour pressure:
0 Pa
Key result
Test no.:
25 °C
Vapour pressure:
0 Pa

Vapour pressure of the test item at 20ºC and 25 ºC was calculated on the basis of equation: log (p) = f (1/t) = a-b/(t+273.15) where: p – vapour pressure in Pa, t – temperature in ºC, obtained for four measurement points: 110.1 ºC, 114.8ºC, 119.1ºC and 123.7ºC.

Table 1. Vapour pressure of the test item.

Test sample


pressure at 20ºC

Vapour pressure at 25ºC

Test item



The vapour pressure of the test item is 1.41E-8 Pa at 20ºC and 4.94E-18 Pa at 25ºC.
Executive summary:

The study of the vapour pressure using effusion method was performed in accordance with the method EU A4 - Knudsen cell, under GLP conditions. The apparatus used, NETZSCH Jupiter STA 449C, makes possible to determine vapour pressure in the range from 10-15 Pa to 500 Pa. The method is based on the estimation of the test substance mass flowing out the Knudsen cell per unit of time, through a micro-orifice under ultra-vacuum conditions. The vapour pressure was calculated by applying the Hertz-Knudsen relation with Clausing correction factor "f" that depends on parameters of the apparatus: on the ratio of orifice length to orifice radius. The vapour pressure of the test item was found to be 1.41E-8 Pa at 20ºC and 4.94E-8 Pa at 25ºC.

Description of key information

Key study. Method according to EU A.4, GLP study. The vapour pressure of the test item is 1.41E-8 Pa at 20ºC and 4.94E-8 Pa at 25ºC.

Key value for chemical safety assessment

Vapour pressure:
0 Pa
at the temperature of:
20 °C

Additional information