Dibenzoyl-L-tartaric acid monohydrate

Vapour pressure

Link to relevant study record(s)

Reference

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

09/09/2018

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

Deviations:

no

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

effusion method: Knudsen cell

Key result

Test no.:

#1

Temp.:

20 °C

Vapour pressure:

0 Pa

Key result

Test no.:

#2

Temp.:

25 °C

Vapour pressure:

0 Pa

Vapour pressure of the test item at 20ºC and 25 ºC was calculated on the basis of equation: log (p) = f (1/t) = a-b/(t+273.15) where: p – vapour pressure in Pa, t – temperature in ºC, obtained for four measurement points: 110.1 ºC, 114.8ºC, 119.1ºC and 123.7ºC.

Table 1. Vapour pressure of the test item.

Test sample	Vapour pressure at 20ºC	Vapour pressure at 25ºC
Test item	1.41E-8Pa	4.94E-8Pa

Conclusions:

The vapour pressure of the test item is 1.41E-8 Pa at 20ºC and 4.94E-18 Pa at 25ºC.

Executive summary:

The study of the vapour pressure using effusion method was performed in accordance with the method EU A4 - Knudsen cell, under GLP conditions. The apparatus used, NETZSCH Jupiter STA 449C, makes possible to determine vapour pressure in the range from 10-15 Pa to 500 Pa. The method is based on the estimation of the test substance mass flowing out the Knudsen cell per unit of time, through a micro-orifice under ultra-vacuum conditions. The vapour pressure was calculated by applying the Hertz-Knudsen relation with Clausing correction factor "f" that depends on parameters of the apparatus: on the ratio of orifice length to orifice radius. The vapour pressure of the test item was found to be 1.41E-8 Pa at 20ºC and 4.94E-8 Pa at 25ºC.

Description of key information

Key study. Method according to EU A.4, GLP study. The vapour pressure of the test item is 1.41E-8 Pa at 20ºC and 4.94E-8 Pa at 25ºC.

Key value for chemical safety assessment

Vapour pressure:

0 Pa

at the temperature of:

20 °C