bis(2,2,6,6-tetramethyl-1-(phenylthio)piperidin-4-yl)carbonate

Melting point / freezing point

Link to relevant study record(s)

Reference

Endpoint:

melting point/freezing point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2018-12-18 to 2019-02-04

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 102 (Melting point / Melting Range)

Version / remarks:

Version adopted July 27, 1995

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.1 (Melting / Freezing Temperature)

Version / remarks:

Version of 31 May 2008

Deviations:

no

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7200 (Melting Point / Melting Range)

Version / remarks:

Version of March 1998

Deviations:

no

Qualifier:

according to guideline

Guideline:

other: OECD Guideline 113 (Screening Test for Thermal Stability and Stability in Air)

Version / remarks:

Version adopted May 12, 1981

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Remarks:

OGYÉI- National Institute of Pharmacy and Nutrition (21.04.2016)

Type of method:

differential scanning calorimetry

Specific details on test material used for the study:

The test item was used in its initial form.

Melting / freezing pt.:

>= 193.01 - <= 198.62 °C

Decomposition:

no

Sublimation:

no

Remarks on result:

other: atm. pressure is stated as normal atmospheric pressure

Appearance of the Samples

Before the test the appearance of the test item was white, crystallic powder. After the experiments it became a black melt in the crucible.

Measurement

The evaluation of the data was performed using the software STARe. As result, a thermogram was obtained in which the heat flow of the investigated sample is given as a function of the temperature. By integrating the area under the heat flow signals, the enthalpy of the process was obtained.

Based on the weight loss and the appearance of the test item after the tests it is concluded that the test item decomposes up to 500 °C.

Table: Summary of the DSC test response

	Experiment 1	Experiment 2	Mean
Onset of effect [°C]	193.35	192.67	193.01
Endset of effect [°C]	198.61	198.63	198.62
Energy [J/g]	-82.00	-84.95	-83.48

Conclusions:

Using a linear heating rate of 10 °C/min the melting point of the test item was determined to be in the range of 193.0 – 198.6 °C (466.2 – 471.8 K).

Executive summary:

For the determination of the melting point differential scanning calorimetry method was used, following internationally accepted guidelines (OECD 102, EU Method A.1) and under GLP compliance. The test was carried out at normal atmospheric pressure.

Applying a linear heating rate, the melting point of the test item was determined to be in the range of 193.0 – 198.6 °C (466.2 – 471.8 K).

Description of key information

For the determination of the melting point differential scanning calorimetry method was used, following internationally accepted guidelines (OECD 102, EU Method A.1) and under GLP compliance. The test was carried out at normal atmospheric pressure.

Applying a linear heating rate, the melting point of the test item was determined to be in the range of 193.0 – 198.6 °C (466.2 – 471.8 K).

Key value for chemical safety assessment

Melting / freezing point at 101 325 Pa:

193 °C

Additional information

The melting point of the test item was determined to be in the range of 193.0 – 198.6 °C. For safety aspects when performing risk assessment, the melting point was set to the lower value (worst case scenario).