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Physical & Chemical properties

Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Guideline study performed under GLP. All relevant validity criteria were met.
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7950 (Vapor Pressure)
Deviations:
no
GLP compliance:
yes
Type of method:
effusion method: isothermal thermogravimetry
Test no.:
#1
Temp.:
20 °C
Vapour pressure:
0.53 Pa
Test no.:
#1
Temp.:
25 °C
Vapour pressure:
0.96 Pa
Test no.:
#2
Temp.:
20 °C
Vapour pressure:
0.47 Pa
Test no.:
#2
Temp.:
25 °C
Vapour pressure:
0.81 Pa
Test no.:
#3
Temp.:
20 °C
Vapour pressure:
0.17 Pa
Test no.:
#3
Temp.:
25 °C
Vapour pressure:
0.36 Pa

The results of the isothermal TGA analysis for the test item and the vapour pressure at 20°C and 25°C are given in the following tables.

 

Table 1.0: Results of the isothermal TGA analysis

Temperature [°C]

Weight loss [µg/min]

νT [g/cm2/h]

log νT

log PT

PT [Pa]

45

5.305

6.33x10^-4

-3.20

0.95

8.9

 

3.781

4.51x10^-4

-3.35

0.78

6.0

 

3.518

4.20x10^-4

-3.38

0.74

5.6

50

8.196

9.78x10^-4

-3.01

1.16

15

 

5.463

6.52x10^-4

-3.19

0.96

9.2

 

6.858

8.19x10^-4

-3.09

1.08

12

55

12.79

1.53x10^-4

-2.82

1.39

24

 

8.367

9.99x10^-4

-3.00

1.18

15

 

10.54

1.26x10^-4

-2.90

1.29

19

Table 2.0 - Vapour Pressure of the test item

Experiment

20°C

25°C

 

Pa

mm Hg

Pa

mm Hg

1

0.53

4.0x10^-3

0.96

7.2x10^-3

2

0.47

3.5x10^-3

0.81

6.0x10^-3

3

0.17

1.3x10^-3

0.36

2.7x10^-3

 

 

 

 

 
Conclusions:
The vapour pressure of the test item was determined to be 0.39 Pa at 20°C (293K) and 0.71 Pa at 25°C (298K), respectively.
Executive summary:

The vapour pressure was determined using the thermogravimetric effusion method in OECD TG 104, EU Method A.4 and US EPA OPPTS 830.7950 under GLP. The vapour pressure of the test item was determined to be in the following ranges, in triplicate respectively: 20°C: 0.17 to 0.53 Pa (or 1.3 x 10^-3 to 4.0 x 10^-3 mm Hg) and 25°C: 0.36 to 0.96 Pa (or 2.7 x 10^-3 to 7.2 x 10^-3 mm Hg). Applicant assessment indicates that the mean (n = 3) vapour pressure of the test item was 0.39 Pa at 20°C and 0.71 Pa at 25°C.

Description of key information

Vapour Pressure: 0.71 Pa at 25 °C (mean, n=3), OECD TG 104 - thermogravimetric effusion method, 2014

Key value for chemical safety assessment

Vapour pressure:
0.71 Pa
at the temperature of:
25 °C

Additional information

Key Study : OECD TG 104, 2015 : The vapour pressure was determined using the thermogravimetric effusion method in OECD TG 104, EU Method A.4 and US EPA OPPTS 830.7950 under GLP. The vapour pressure of the test item was determined to be in the following ranges, in triplicate respectively: 20°C: 0.17 to 0.53 Pa (or 1.3 x 10^-3 to 4.0 x 10^-3 mm Hg) and 25°C: 0.36 to 0.96 Pa (or 2.7 x 10^-3 to 7.2 x 10^-3 mm Hg). Applicant assessment indicates that the mean (n = 3) vapour pressure of the test item was 0.39 Pa at 20°C and 0.71 Pa at 25°C.