Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 453-490-7 | CAS number: -
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
No effects up to the limit of water solubility (OECD 211).
Key value for chemical safety assessment
Additional information
The hazard assessment is based on the data currently available. New studies with the registered substance and/or other member substances of the polyol esters family will be conducted in the future. The finalised studies will be included in the technical dossier as soon as they become available, and the hazard assessment will be re-evaluated accordingly.
Since no studies investigating the long-term toxicity of Fatty acids C5-10 esters with dipentaerythritol (CAS 70983-72-1) to aquatic invertebrates are available, in accordance to Regulation (EC) No 1907/2006, Annex XI, 1.5 a read-across to the structurally related source substance Carboxylic acids, C5-9, hexaesters with dipentaerythritol (CAS 67762-52-1) was conducted. The source substance Carboxylic acids, C5-9, hexaesters with dipentaerythritol is structurally similar to the target substance. This read-across is justified in detail in the analogue justification in IUCLID Section 13.
The study with the source substance was conducted according to OECD 211 (GLP) with Daphnia magna as test organism. Since the test item is poorly soluble in water three different loading rates were prepared (1, 10 and 100 mg/L). The water accommodated fractions (WAFs) were prepared by adding appropriate amounts of the test item to test medium followed by 95 h stirring and 1 h settling period. The aqueous phase was removed by mid-depth siphoning. Microscopic observations did not indicate any undissolved micro-dispersions or undissolved test material. After semi-static exposure for 21 days no significant effects on the survival and reproduction rate were determined. A NOELR (21 d) ≥ 100 mg/L was derived. The validity criteria are met indicating that the study results are considered to be valid.
Based on the available result from one structurally related source substance (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) which is characterized by a similar ecotoxicological profile and comparable structure, it can be concluded that the same result is expected when testing the target substance.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
