Registration Dossier
Registration Dossier
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EC number: 671-273-7 | CAS number: 22245-83-6
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in mammalian cells
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Peer review of the pesticide risk assessment of the active substance flazasulfuron
- Author:
- European Food Safety Authority (EFSA)
- Year:
- 2 016
- Bibliographic source:
- EFSA Journal 2016;14(8):4575
Materials and methods
- Principles of method if other than guideline:
- - Principle of test:
not reported
- Short description of test conditions: not reported
- Parameters analysed / observed: in vitro mutagenicity in mammalian cells - GLP compliance:
- not specified
- Type of assay:
- in vitro mammalian cell gene mutation tests using the thymidine kinase gene
Test material
- Reference substance name:
- 3-(trifluoromethyl)pyridin-2(1H)-one
- EC Number:
- 671-273-7
- Cas Number:
- 22245-83-6
- Molecular formula:
- C6H4F3NO
- IUPAC Name:
- 3-(trifluoromethyl)pyridin-2(1H)-one
- Test material form:
- not specified
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- not specified
- Metabolic activation:
- not specified
Controls
- Untreated negative controls:
- not specified
- Negative solvent / vehicle controls:
- not specified
- True negative controls:
- not specified
- Positive controls:
- not specified
Results and discussion
Test results
- Key result
- Species / strain:
- not specified
- Metabolic activation:
- not specified
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- True negative controls validity:
- not specified
- Positive controls validity:
- not specified
Applicant's summary and conclusion
- Conclusions:
- The test material was reported to be negative (not mutagenic) in the Mouse Lymphoma Assay.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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