Registration Dossier
Registration Dossier
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EC number: 206-735-5 | CAS number: 371-40-4
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Study period:
- 1979-01-17 to 1979-02-13
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- 3-chloro-4-fluoroaniline
- EC Number:
- 206-682-8
- EC Name:
- 3-chloro-4-fluoroaniline
- Cas Number:
- 367-21-5
- Molecular formula:
- C6H5ClFN
- IUPAC Name:
- 3-chloro-4-fluoroaniline
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- NMRI
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation (mean): Male: 20-22 g; Female: 20-28 g
- Fasting period before study: 15-20 hours before application
- Diet: From Herilan MRH-Haltung; H. Eggersmann KG
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- CMC (carboxymethyl cellulose)
- Remarks:
- 0.5 % aqu. solution
- Details on exposure:
- Applied volume: 10 mL/kg bw
- Doses:
- 700, 200 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Daily
- Necropsy of survivors performed: Yes
- Examinations performed: Clinical signs, body weight
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 700 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Male:
700 mg/kg bw: 3 animals
200 mg/kg bw: 0 animals
Female:
700 mg/kg bw: 1 animal
200 mg/kg bw: 0 animals - Clinical signs:
- At 700 mg/kg bw:
Dyspnoea, apathy, stagger, tremble, spastic gait, balance disturbance, clonic cramp, cyanosis etc.
At 200 mg/kg bw
Dyspnoea, agitation, stagger, cyanosis - Body weight:
- No effects reported
- Gross pathology:
- No intra-abdominal substance precipitation or adhesion.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
