7-ethoxy-4,6-difluoro-dibenzothiophen-3-ol

Particle size distribution (Granulometry)

Link to relevant study record(s)

Reference

Endpoint:

particle size distribution (granulometry)

Type of information:

experimental study

Adequacy of study:

key study

Study period:

March 12, 2019

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions) - Method B: Fibre Length and Diameter Distributions

Deviations:

no

GLP compliance:

no

Type of method:

sieving

Type of particle tested:

primary particle

Type of distribution:

volumetric distribution

Percentile:

D10

Mean:

400 µm

Remarks on result:

other: St. dev not determined

Key result

Percentile:

D50

Mean:

750 µm

Remarks on result:

other: St. dev not determined

Percentile:

D90

Mean:

5 000 µm

Remarks on result:

other: St. dev not determined

The particle size distribution was determined by dry sieving as only approximately 38 % of the test item passed a 1000 µlm sieve and thus laser diffraction was not applicable. 129.17 g of the test item were placed on the top sieve. After closing the sieve stack and placing it into the sieving machine sieving was performed for 10 min with an amplitude of 1.0 mm.

Table 1: Sieving analysis

Mesh size µm	Range of particle size µm	Retained fraction g	Retained fraction %	Cumulative retained %	Cumulative passing %
5000	>5000	12.93	10.01	10.01	89.99
3350	3350 - 5000	5.03	3.89	13.90	86.10
2000	2000 - 3350	10.05	7.78	21.68	78.32
1000	1000-2000	14.37	11.12	32.81	67.19
800	800-1000	17.70	13.70	46.51	53.49
630	630 - 800	31.66	24.51	71.02	28.98
500	500 - 630	21.64	16.75	87.78	12.22
250	250 - 500	8.10	6.27	94.05	5.95
Receiver pan	0-250	7.54	5.84	99.88	0.12

 

The test item tended to build up spherical agglomerates during the measurement. This might have influenced the results of the measurement.

Conclusions:

The particle size distribution of the test item was determined by dry sieving to be D50 = 750 µm.

Executive summary:

A study was conducted according to OECD TG 110 and DIN66165 part 1 and 2: Sieving analysis in order to determine the particle size distribution of the test item. The particle size distribution was determined by dry sieving as only approximately 38 % of the test item passed a 1000 µm sieve and thus laser diffraction was not applicable. The mesh sizes of the sieves were chosen after an optical inspection to cover the whole range of particle sizes as far as possible. 129.17 g of the test item were placed on the top sieve. After closing the sieve stack and placing it into the sieving machine sieving was performed for 10 min with an amplitude of 1.0 mm. From the measured amount of test item on each sieve the particle size distribution was calculated. The particle size D50 was determined to be 750 µm.

Description of key information

The particle size distribution of the test item was determined by dry sieving to be D50 = 750 µm (reference 4.5-1).

Additional information

A study was conducted according to OECD TG 110 and DIN66165 part 1 and 2: Sieving analysis in order to determine the particle size distribution of the test item. The particle size distribution was determined by dry sieving as only approximately 38 % of the test item passed a 1000 µm sieve and thus laser diffraction was not applicable. The mesh sizes of the sieves were chosen after an optical inspection to cover the whole range of particle sizes as far as possible. 129.17 g of the test item were placed on the top sieve. After closing the sieve stack and placing it into the sieving machine sieving was performed for 10 min with an amplitude of 1.0 mm. From the measured amount of test item on each sieve the particle size distribution was calculated. The particle size D50 was determined to be 750 µm.