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EC number: 434-050-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
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- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
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- Additional toxicological data

Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2003-09-02 to 2003-09-13
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 1995
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- 1992
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- signed, 2003-03
- Type of method:
- column elution method
- Specific details on test material used for the study:
- Appearance: Solid
Storage: At room temperature at about 20 °C - Water solubility:
- < 63.6 µg/L
- Conc. based on:
- test mat. (dissolved fraction)
- Loading of aqueous phase:
- 1.4 g/L
- Incubation duration:
- 86 h
- Temp.:
- 20 °C
- pH:
- ca. 7.4
- Conclusions:
- The water solubility of the test item at 20 ° C was determined to be < 0.0636 mg/L using the column elution method.
Reference
Results of the water solubility of the test item
Experiment No. |
Flow rate [mL/h] |
Sample No. |
Concentration analysed [μg/mL) |
Water solubility calculated [mg/L] |
pH
|
1 |
31 |
1 2 3 4 5 6 |
< 0.06364 < 0.06364 < 0.06364 < 0.06364 < 0.06364 < 0.06364 |
< 0.06364 |
7.41 7.38 7.36 7.39 7.40 7.41 7.39 7.42 7.38 7.37 7.39 7.41 |
2 |
16 |
7 8 9 10 11 12 |
< 0.06364 < 0.06364 < 0.06364 < 0.06364 < 0.06364 < 0.06364 |
During the preliminary test the water solubility of the test substance at room temperature was estimated by a simplified flask method to be lower than the smallest calibration point of 0.0636 μg/mL. Therefore the column elution method was used for the performance of the main test.
During the main test six samples have been analysed in the first run (0.52 mL/min) and six samples during the second run (0.26 mL/min), each with a sampling interval of one hour. Total elution time was 86 hours. The sample measurement was performed by HPLC. The measured results differ by less than 30 %. Therefore the study is considered to be valid.
The test item could not be detected in any of the eluate samples.
In conclusion, the water solubility of the test substance at 20 °C was determined to be < 0.0636 mg/L using the column elution method.
Description of key information
The water solubility of the test item at 20 °C was determined to be < 63.6 µg/L using the column elution method.
Key value for chemical safety assessment
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