Registration Dossier
Registration Dossier
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EC number: 203-464-4 | CAS number: 107-12-0
Endpoint summary
Administrative data
Description of key information
A large amount of studies is available on the acute toxicity of propionitrile. The most relevant available studies for classification have been added as indiviudal entries.
An overview of all acute toxicity studies is given in the literature list attached in section 13.
Key value for chemical safety assessment
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
Acute oral toxicity:
Many studies report oral LD50 values between 5 and 50 mg/kg bw (see literature list section 13). These are however no longer available or not enough details are available to fully assess their validity. However, as multiple such studies are available, this information should not be ignored. The study from Bhattacharya et al. 2009 is the most relevant study available study for acute oral toxicity where enough details are available (LD50 = 123 mg/kg bw). Additionally, the study from Willwhite is relevant to consider for acute oral toxicity (LD50 = 28 mg/kg bw): propionitrile was injected intraperitoneally and this route of exposure is thus closely related to oral uptake.
Based on these lines of evidence, propionitrile was considered acute toxic after oral uptake and classified as Acute Tox 2.
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