Propiononitrile

Endpoint summary

Description of key information

For skin irritation/corrosion, read-across was performed based on 9 category members. No skin irritating properties are expected. Additionally, a reliable handbook reference is available that reports no evidence for skin irritation.

Based on these two elements, propionitrile is consided not irritating to the skin.

For eye irritation, read-across was performed based on 9 category members. The read-across did not predict eye irritation properties but it should be noted that two closely related substances in the database were classified for eye irritation (Cat 2). Additionally, a reliable handbook reference is available that reports mildly irritating effects on the eye.

Based on this information, propionitrile can be irritating to the eyes and therefore propionitrile was classified as Eye Irrit 2.

Key value for chemical safety assessment

Skin irritation / corrosion

Link to relevant study records

Reference

Reference 1

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Qualifier:

no guideline available

Principles of method if other than guideline:

No further details are provided but this study has been peer reviewed by the US National Institute for Occupational Safety and Health (NIOSH) and is therefore considered a credible source.

GLP compliance:

not specified

Species:

rabbit

Basis:

mean

Time point:

24 h

Remarks on result:

positive indication of irritation

Remarks:

Mild irritation of the skin was observed after 24 hours at a dose of 500 mg proprionitrile

Interpretation of results:

Category 3 (mild irritant) based on GHS criteria

Conclusions:

Moderate effects on the eyes of rabbits were observed after 24 hours at a dose of 100 mg.

Reference 2

Endpoint:

skin irritation: in vivo

Type of information:

read-across based on grouping of substances (category approach)

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification

Justification for type of information:

REPORTING FORMAT FOR THE CATEGORY APPROACH
See attached documentation

Qualifier:

according to guideline

Guideline:

other: Guidance on information requirements and chemical safety assessment Chapter R.6: QSARs and grouping of chemicals

Remarks on result:

no indication of irritation

Remarks:

Based on read-across from 8 category members

Interpretation of results:

GHS criteria not met

Conclusions:

Based on the read-across from closely related substances (unbranched nitriles), propionitrile is not expected to cause skin irritation or corrosion.

Endpoint conclusion

Endpoint conclusion:

no adverse effect observed (not irritating)

Eye irritation

Link to relevant study records

Reference

Reference 1

Endpoint:

eye irritation: in vivo

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Qualifier:

no guideline available

Principles of method if other than guideline:

No further details are provided but this study has been peer reviewed by the US National Institute for Occupational Safety and Health (NIOSH) and is therefore considered a credible source.

GLP compliance:

not specified

Species:

rabbit

Strain:

not specified

Vehicle:

not specified

Controls:

not specified

Irritation parameter:

other:

Basis:

mean

Time point:

24 h

Remarks on result:

positive indication of irritation

Remarks:

Moderate effects were observed at a dose of 100 mg

Interpretation of results:

Category 2 (irritating to eyes) based on GHS criteria

Conclusions:

Moderate effects on the eyes of rabbits were observed after 24 hours at a dose of 100 mg.

Reference 2

Endpoint:

eye irritation: in vivo

Type of information:

read-across based on grouping of substances (category approach)

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification

Justification for type of information:

REPORTING FORMAT FOR THE CATEGORY APPROACH
See attached documentation for a detailed description of the read-across approach.

Qualifier:

according to guideline

Guideline:

other: Guidance on information requirements and chemical safety assessment Chapter R.6: QSARs and grouping of chemicals

Remarks on result:

no indication of irritation

Remarks:

Based on a read-across from 8 category members

Remarks on result:

other: Acetonitrile and oxalonitrile are two category members that have a very similar log Kow and that are considered irritating to the eyes. Although no eyeye irritation is predicted based on all 8 category members, it cannot be excluded based on these two.

Interpretation of results:

GHS criteria not met

Conclusions:

Based on the read-across from 8 category members (unbranched nitriles), no eye irritation is predicted for propionitrile.

Endpoint conclusion

Endpoint conclusion:

adverse effect observed (irritating)