(Z)-non-6-enal

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

documentation insufficient for assessment

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1978

Report date:

1978

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

GLP compliance:

no

Test type:

fixed dose procedure

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

(Z)-non-6-enal

EC Number:

218-900-9

EC Name:

(Z)-non-6-enal

Cas Number:

2277-19-2

Molecular formula:

C9H16O

IUPAC Name:

(Z)-non-6-enal

Test material form:

liquid

Test animals

Species:

rat

Strain:

not specified

Sex:

not specified

Administration / exposure

Route of administration:

oral: unspecified

Vehicle:

not specified

Doses:

5 g/kg

No. of animals per sex per dose:

10

Control animals:

no

Details on study design:

- Duration of observation period following administration: at least 8 days
- Necropsy of survivors performed: yes
- Clinical signs including body weight: yes
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other:

Statistics:

95% confidence limit

Results and discussion

Effect levels

Key result

Sex:

not specified

Dose descriptor:

LD50

Effect level:

> 5 000 mg/kg bw

Based on:

not specified

Mortality:

One of ten animals died on day 8 of the study.

Clinical signs:

other: Alopecia

Gross pathology:

Eight animals were normal at necropsy. One animals showed brown exudate fromt the anogenital area. One animal had red areas in the intestines. One animal had a dark liver, and one animal had dark areas of the lungs.

Any other information on results incl. tables

	Number of Animals
Mortality on Day 8	1
Normal Necropsy	8
Exudate, Anogential, Brown	1
Intestines, Areas Red	1
Liver Dark	1
Lungs, Areas Dark	1

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

The acute oral LD50 is greater than 5000 mg/kg.

Executive summary:

The acute oral toxicity of the test substance was tested by exposing 10 rats orally to 5,000 mg/kg of the test substance. One animal died eight days after exposure. The acute oral LD50 is therefore greater than 5000 mg/kg.