Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Skin irritation OECD 404: not irritating

Eye irritation OECD 405: not irritating

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Skin irritation:

A skin irritation study with six rabbits was performed (4 hours application) with the substance according to OECD 404 test guideline.

No skin reaction such as erythema (red spots) or edema (swelling) was observed throughout the observation period of 72 hours.

None of the tested animals were found affected by the test substance and there were no significant changes in general condition and body weight.

Eye irritation:

An in vivo eye irritation study was performed with the substance in accordance with OECD 405 (1987) and according to GLP principles. An amount of approximately 70 mg of MDI/CHA/ODA/DCHA was instilled in one of the eyes of 3 rabbits, followed by an observation period of 72 hours. Instillation of the test substance affected the conjunctivae of all 3 animals. The effects were reversible within 24 hours in 1 animal and within 72 hours in the other 2 animals. No corrosive effects and no clinical signs of toxicity were observed.

Justification for classification or non-classification

Based on the results of the studies it is concluded that MDI/CHA/ODA/DCHA does not need to be classified for skin or eye irritation according to Regulation (EC) No. 1272/2008.