Registration Dossier
Registration Dossier
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EC number: 406-550-1 | CAS number: - MDI
Endpoint summary
Administrative data
Description of key information
Skin irritation OECD 404: not irritating
Eye irritation OECD 405: not irritating
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation:
A skin irritation study with six rabbits was performed (4 hours application) with the substance according to OECD 404 test guideline.
No skin reaction such as erythema (red spots) or edema (swelling) was observed throughout the observation period of 72 hours.
None of the tested animals were found affected by the test substance and there were no significant changes in general condition and body weight.
Eye irritation:
An in vivo eye irritation study was performed with the substance in accordance with OECD 405 (1987) and according to GLP principles. An amount of approximately 70 mg of MDI/CHA/ODA/DCHA was instilled in one of the eyes of 3 rabbits, followed by an observation period of 72 hours. Instillation of the test substance affected the conjunctivae of all 3 animals. The effects were reversible within 24 hours in 1 animal and within 72 hours in the other 2 animals. No corrosive effects and no clinical signs of toxicity were observed.
Justification for classification or non-classification
Based on the results of the studies it is concluded that MDI/CHA/ODA/DCHA does not need to be classified for skin or eye irritation according to Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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