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Diss Factsheets

Administrative data

Link to relevant study record(s)

oxidising liquids
Type of information:
experimental study
Adequacy of study:
key study
Study period:
12 October to 14 December 2010
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions
The study was conducted according to an internationally recognised method, and under GLP. No deviation affected the quality of the study. The substance is adequately identified, but some data on composition is missing. Therefore validation applies with restrictions.
according to guideline
EU Method A.21 (Oxidising Properties (Liquids))
Version / remarks:
Regulation (EC) No 440/2008
Principles of method if other than guideline:
Not applicable
GLP compliance:
yes (incl. QA statement)
issued on 12/01/2007
Specific details on test material used for the study:
Storage condition of test material: The test item was stored in a closed vessel at room temperature (20 +/-5°C).
Contact with:
powdered cellulose
Duration of test (contact time):
120 s
Key result
Sample tested:
test mixture 1:1
2.5 g of the liquid to be tested was mixed with 2.5 g of dried cellulose
mean pressure rise time
>= 23 s
Sample tested:
reference mixture with 65% nitric acid + cellulose (1:1 ratio)
mean pressure rise time
>= 6.09 - <= 6.9 s

Mixture Replicate Time lapse between 690 kPa and 2070 kPa (s) Mean time lapse (s) Difference to mean (%)
test item : cellulose
1 (2070 kPa not reach in 60 s test time) 28 -
2 25 -12%
3 23 -22%
4 33 15%
5 31 -10%
HNO3 65% : cellulose
1 6,90 6,65 -3,8%
2 6,74 -1,4%
3 6,09 8,4%
4 6,89 -3,6%
5 6,67 -0,3%

Result: The test item is considered as NOT oxidising, as the increase in pressure took place very slowly, taking much more time than the reference mixture.


Validity: In a series of five trials, no result should differ by more than 30 % from the arithmetic mean. Results that differ by more than 30 % from the mean should be discarded, the mixing and filling procedure is improved and the testing is repeated.

No result differed by more than 30% from the mean.



All validity criteria of the reference were met.

No signs of oxidising properties of the test item were detected.

The reference item showed oxidising properties very clearly and with good repeatability.

No observations were made which might cause doubts concerning the validity of the study outcome.

The result of the test is considered valid.

Interpretation of results:
GHS criteria not met
The test item is Not an oxidizing liquid, based on slow pressure rise.
Executive summary:

The oxidising properties of the substance were tested under GLP, according to the EU A.21 guideline.

A 1:1 mixture with cellulose was used. In the five independant replicates, the bursting disc was not damaged, and the increase in pressure was much slower (> 23 s) than the reference mixture with nitric acid (< 7 s).

Therefore the test item must be considered as not oxidising.

Description of key information

Experimental pressure rise slower than reference.

Key value for chemical safety assessment

Oxidising properties:
non oxidising

Additional information

A reliable experimental study, conducted according to a recognized EC method and under GLP, is available. Despite restrictions due to incomplete test item identification, it is considered as key study, and the result is retained as key data.

Justification for classification or non-classification

According to CLP and GHS criteria, a 1:1 mixture of test substance with cellulose had a slower pressure rise than the reference mixture with HNO3 65%, therefore the substance is NOT considered as an oxidising liquid.