Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1976
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: TRD Protocol No. 30, Book 1, p.389
- Principles of method if other than guideline:
- Single Oral Dose
Species Albino Male Rat
Condition: Animals fasted for 24 hours were dosed with the product as received. - GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Reaction mass of 2-(3a,4,5,6,7,7a-hexahydro-1H-4,7-methanoinden-5-yloxy)ethyl acrylate and 2-(3a,4,5,6,7,7a-hexahydro-1H-4,7-methanoinden-6-yloxy)ethyl acrylate
- Molecular formula:
- C15 H20 O3
- IUPAC Name:
- Reaction mass of 2-(3a,4,5,6,7,7a-hexahydro-1H-4,7-methanoinden-5-yloxy)ethyl acrylate and 2-(3a,4,5,6,7,7a-hexahydro-1H-4,7-methanoinden-6-yloxy)ethyl acrylate
Constituent 1
- Specific details on test material used for the study:
- No specific details on test material.
Test animals
- Species:
- rat
- Strain:
- other: CF Nelson
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- Species: Albino Male Rat
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- Animals fasted for 24 hours were dosed with the product, as received.
- Doses:
- 5.0 g/kg
- No. of animals per sex per dose:
- Ten
- Control animals:
- no
- Details on study design:
- No further details specified.
Results and discussion
Effect levels
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- One male died on day 3.
- Clinical signs:
- other: Signs of intoxication: Piloerection, lethargy, prostration, ataxia.
- Gross pathology:
- Gross autopsy on survivors found no visible lesions.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- LD50 greater than 5000 mg/kg
- Executive summary:
Single Oral Dose: Species Albino Male Rat
Condition: Animals fasted for 24 hours were dosed with the product as received.
Dosage: 5.0 g/kg
Died/dosed: 1/10
LD50 greater than 5.0 g/kg
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