[No public or meaningful name is available]

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1976

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

test procedure in accordance with national standard methods with acceptable restrictions

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1976

Report date:

1976

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: TRD Protocol No. 30, Book 1, p.389

Principles of method if other than guideline:

Single Oral Dose
Species Albino Male Rat
Condition: Animals fasted for 24 hours were dosed with the product as received.

GLP compliance:

no

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Reaction mass of 2-(3a,4,5,6,7,7a-hexahydro-1H-4,7-methanoinden-5-yloxy)ethyl acrylate and 2-(3a,4,5,6,7,7a-hexahydro-1H-4,7-methanoinden-6-yloxy)ethyl acrylate

Molecular formula:

C15 H20 O3

IUPAC Name:

Reaction mass of 2-(3a,4,5,6,7,7a-hexahydro-1H-4,7-methanoinden-5-yloxy)ethyl acrylate and 2-(3a,4,5,6,7,7a-hexahydro-1H-4,7-methanoinden-6-yloxy)ethyl acrylate

Specific details on test material used for the study:

No specific details on test material.

Test animals

Species:

rat

Strain:

other: CF Nelson

Sex:

male

Details on test animals or test system and environmental conditions:

Species: Albino Male Rat

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

unchanged (no vehicle)

Details on oral exposure:

Animals fasted for 24 hours were dosed with the product, as received.

Doses:

5.0 g/kg

No. of animals per sex per dose:

Ten

Control animals:

no

Details on study design:

No further details specified.

Results and discussion

Effect levels

Key result

Sex:

male

Dose descriptor:

LD50

Effect level:

> 5 000 mg/kg bw

Based on:

test mat.

Mortality:

One male died on day 3.

Clinical signs:

other: Signs of intoxication: Piloerection, lethargy, prostration, ataxia.

Gross pathology:

Gross autopsy on survivors found no visible lesions.

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

LD50 greater than 5000 mg/kg

Executive summary:

Single Oral Dose: Species Albino Male Rat

Condition: Animals fasted for 24 hours were dosed with the product as received.

Dosage: 5.0 g/kg

Died/dosed: 1/10

LD50 greater than 5.0 g/kg