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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1976
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
test procedure in accordance with national standard methods with acceptable restrictions

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1976
Report date:
1976

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: TRD Protocol No. 30, Book 1, p.389
Principles of method if other than guideline:
Single Oral Dose
Species Albino Male Rat
Condition: Animals fasted for 24 hours were dosed with the product as received.
GLP compliance:
no
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Reaction mass of 2-(3a,4,5,6,7,7a-hexahydro-1H-4,7-methanoinden-5-yloxy)ethyl acrylate and 2-(3a,4,5,6,7,7a-hexahydro-1H-4,7-methanoinden-6-yloxy)ethyl acrylate
Molecular formula:
C15 H20 O3
IUPAC Name:
Reaction mass of 2-(3a,4,5,6,7,7a-hexahydro-1H-4,7-methanoinden-5-yloxy)ethyl acrylate and 2-(3a,4,5,6,7,7a-hexahydro-1H-4,7-methanoinden-6-yloxy)ethyl acrylate
Specific details on test material used for the study:
No specific details on test material.

Test animals

Species:
rat
Strain:
other: CF Nelson
Sex:
male
Details on test animals or test system and environmental conditions:
Species: Albino Male Rat

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Details on oral exposure:
Animals fasted for 24 hours were dosed with the product, as received.
Doses:
5.0 g/kg
No. of animals per sex per dose:
Ten
Control animals:
no
Details on study design:
No further details specified.

Results and discussion

Effect levels
Key result
Sex:
male
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Mortality:
One male died on day 3.
Clinical signs:
other: Signs of intoxication: Piloerection, lethargy, prostration, ataxia.
Gross pathology:
Gross autopsy on survivors found no visible lesions.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
LD50 greater than 5000 mg/kg
Executive summary:

Single Oral Dose: Species Albino Male Rat

Condition: Animals fasted for 24 hours were dosed with the product as received.

Dosage: 5.0 g/kg

Died/dosed: 1/10

LD50 greater than 5.0 g/kg