1,4,10,13-pentaoxacyclopentadecane

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Title:

Oral Toxicity of the Cyclic Polyethers-12-crown-4, 15-crown-5, and 18-crown-6-in Mice

Author:

RICHARD R. HENDRIXSON

Year:

1978

Bibliographic source:

Toxicology and applied Pharmacology 44,263-268 (1978)

Materials and methods

Principles of method if other than guideline:

The lethality study was performed on male mice. Aqueous solutions (0.5 ml) of the compounds were administered by stomach intubation. All fatalities occurred within 3 days and were attributed to the crown ether. The LD16, LD50, and LD84 were determined by the method of Litchfield and Wilcoxon (1949).

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

1,4,10,13-pentaoxacyclopentadecane

EC Number:

251-379-6

EC Name:

1,4,10,13-pentaoxacyclopentadecane

Cas Number:

33100-27-5

Molecular formula:

C10H20O5

IUPAC Name:

1,4,7,10,13-pentaoxacyclopentadecane

Test animals

Species:

mouse

Strain:

CD-1

Sex:

male

Administration / exposure

Route of administration:

other: Stomach intubation

Control animals:

no

Results and discussion

Effect levels

Key result

Sex:

male

Dose descriptor:

LD50

Effect level:

1 020 mg/kg bw

Based on:

test mat.

Applicant's summary and conclusion

Conclusions:

Oral LD50 (Mice, male): 1020 mg/kg bw