Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Title:
Oral Toxicity of the Cyclic Polyethers-12-crown-4, 15-crown-5, and 18-crown-6-in Mice
Author:
RICHARD R. HENDRIXSON
Year:
1978
Bibliographic source:
Toxicology and applied Pharmacology 44,263-268 (1978)

Materials and methods

Principles of method if other than guideline:
The lethality study was performed on male mice. Aqueous solutions (0.5 ml) of the compounds were administered by stomach intubation. All fatalities occurred within 3 days and were attributed to the crown ether. The LD16, LD50, and LD84 were determined by the method of Litchfield and Wilcoxon (1949).
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
1,4,10,13-pentaoxacyclopentadecane
EC Number:
251-379-6
EC Name:
1,4,10,13-pentaoxacyclopentadecane
Cas Number:
33100-27-5
Molecular formula:
C10H20O5
IUPAC Name:
1,4,7,10,13-pentaoxacyclopentadecane

Test animals

Species:
mouse
Strain:
CD-1
Sex:
male

Administration / exposure

Route of administration:
other: Stomach intubation
Control animals:
no

Results and discussion

Effect levels
Key result
Sex:
male
Dose descriptor:
LD50
Effect level:
1 020 mg/kg bw
Based on:
test mat.

Applicant's summary and conclusion

Conclusions:
Oral LD50 (Mice, male): 1020 mg/kg bw