Registration Dossier
Registration Dossier
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EC number: 601-489-9 | CAS number: 1176-81-4
Density
Administrative data
Link to relevant study record(s)
- Endpoint:
- relative density
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 07 Aug 2017 - 18 Jan 2018
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 109 (Density of Liquids and Solids)
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method A.3 (Relative Density)
- GLP compliance:
- no
- Other quality assurance:
- ISO/IEC 17025 (General requirements for the competence of testing and calibration laboratories)
- Type of method:
- pycnometer method
- Key result
- Type:
- relative density
- Density:
- 1.236 other: dimensionless
- Temp.:
- 20 °C
- Remarks on result:
- other: mean value of 2 determinations
- Conclusions:
- The density of Fluocortolon-A-Acetat at 20 ºC was 1.236 g/cm3 and the relative density was 1.236.
- Executive summary:
The relative density of Fluocortolon-A-Acetat was determined according to the OECD Guideline 109 (Density of Liquids and Solids) corresponding to A.3., Council Regulations EC No 440/2008. The solid sample was accurately weighed into a 20 mL pycnometer and by displacement of the solvent (n-heptan), its equivalent volume was determined. Finally, the density of Fluorcortolon-A-Acetat was calculated. The relative density at 20 ºC was 1.236 g/cm³ and the relative density was 1.236.
Reference
Literature data (CRC Handbook of Chemistry and Physics 75th Edition)
d (20, w) (density of water at 20 °C) = 0.9982 g/mL
d (4, w) (density of water at 4 °C) = 0.99997 g/mL
d (20, a) (density of air at 20 °C) = 0.0012 g/mL
Validity criteria for the measurement of the density:
| Target condition according to guideline: | Actual condition according to the study: | Validity criteria met: |
| The test is done at constant temperature, preferably at 20°C. | The pycnometer was thermostated at 20 °C in a water bath until the readings of the filling height remained constant. | Yes |
| Duplicate measurements are required. | Two measurements are performed. | Yes |
Description of key information
The relative density of Fluocortolon-A-Acetat was determined according to the OECD Guideline 109 (Density of Liquids and Solids) corresponding to A.3., Council Regulations EC No 440/2008 by pycnometer method. The relative density at 20 ºC was 1.236 g/cm3and the relative density was 1.236.
Key value for chemical safety assessment
- Relative density at 20C:
- 1.236
Additional information
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