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EC number: 247-384-8 | CAS number: 25973-55-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable study report with restrictions (only one test concentration, occlusive dressing, limited data on test material, only 2 animals per dose and the skin of half of the animals was abraded, no GLP)
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 969
- Report date:
- 1969
- Reference Type:
- other: Correspondence
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- (only one test concentration, occlusive dressing, limited data on test material, only 2 animals per dose and the skin of half of the animals was abraded)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2-(2H-benzotriazol-2-yl)-4,6-ditertpentylphenol
- EC Number:
- 247-384-8
- EC Name:
- 2-(2H-benzotriazol-2-yl)-4,6-ditertpentylphenol
- Cas Number:
- 25973-55-1
- Molecular formula:
- C22H29N3O
- IUPAC Name:
- 2-(2H-benzotriazol-2-yl)-4,6-bis(1,1-dimethylpropyl)phenol
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: Albino Rabbits
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: Young adult albino rabbits
- Weight at study initiation: Mean bodyweight of about 3 kg
- Housing: Individual cages
- Diet: standard rabbit ration
- Water (ad libitum)
- Acclimation period: At least 7 days
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- polyethylene glycol
- Details on dermal exposure:
- TEST SITE
- 24 hours before dermal application, the backs of the rabbits were shaved free of hair with electric clippers
- One rabbit of each sex was further prepared by making epidermal abrasions every 2 or 3 cm longitudinally over the area of exposure; the abrasions were sufficiently deep to penetrate the stratum corneum, but not cause bleeding.
- Area of exposure: Back
- % coverage: 10% of total surface-area
- Type of wrap if used: Impervious plastic sheeting securely taped in place to ensure intimate contact of epidermis and test material
REMOVAL OF TEST SUBSTANCE
- Washing (if done): The animals were thoroughly cleaned. No further details.
- Time after start of exposure: 24 hours
TEST MATERIAL
- Amount: 3 g of the test substance prepared as cream with polyethylene glycol
- For solids, paste formed: yes - Duration of exposure:
- 24 hours
- Doses:
- 1100 mg/kg bw
- No. of animals per sex per dose:
- 2
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: No details
- Frequency of weighing: At start and end of the study.
- Necropsy of survivors performed: yes
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 1 100 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No mortality occured.
- Mortality:
- No mortality occured.
- Clinical signs:
- other: - Scarified animal sites: Behaviour normal, very slight erythema at 24 hours, reversible within 72 hours - Unscarified animal sites: Behaviour normal, very slight erythema and well-defined erythema at 24 hours, reversible within 72 hours This application
- Gross pathology:
- - Scarified animals: nothing unusual at autopsy
- Unscarified animals: nothing unusual at autopsy
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

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