Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 247-891-4 | CAS number: 26658-19-5
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
No toxic effects up to the limit of water solubility for Oryzias latipes (Circular on Test Methods of New Chemical Substances (Japan), Fish acute toxicity test); read-across
Key value for chemical safety assessment
Additional information
No studies are available on the toxicity of Sorbitan tristearate (CAS 26658-19-5) to fish. The assessment was, therefore, based on a study conducted with the structurally similar category member Sorbitan stearate (CAS No. 1338-41-6). This read across approach is in accordance with Regulation (EC) No 1907/2006, Annex XI, 1.5. Grouping of substance and read across approach. Sorbitan tristearate and Sorbitan stearate are both Sorbitan esters of saturated C18 fatty acids. Since the Sorbitan stearate mainly consists of monoesters, it can be considered a worst case read-across to Sorbitan tristearate, which is expected to be less bioavailable due to its molecular size (MW 879-982).
The key study conducted with Sorbitan stearate (CAS No.1338-41-6) was performed as a limit test, according to the Circular on Test Methods of New Chemical Substances (Japan), in a semi-static system, using Oryzias latipes as test organism (Ministry of the Environment, Japan, 2005). The fish were exposed to the nominal test concentration of 1000 mg/L, prepared as water accommodated fractions (WAF). No mortalities were observed at the test concentration, during the 96-hour test period, and the LL50 was determined to be > 1000 mg/L. The reported measured value LC50 > 13.7 mg/L is far above the solubility of the test substance and is therefore questionable. Since additionally the substance is an UVCB and the test was performed as WAF, the nominal loading rate was considered more appropriate to be used for the assessment.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
