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Description of key information

Key value for chemical safety assessment

Additional information

No valid key studies are available for the assessment of the toxicokinetics, metabolism and distribution of citronellyl acetate.

Based on its physicochemical properties, i. e. small molecular weight, LogPow and low to moderate water solubility at room temperature (MW=198.3, Log Kow = 4.9, water solubility = 15.9 mg/L), citronellyl acetate is considered to become readily bioavailable via the dermal and oral route. On the basis of the low vapour pressure at room temperature (vapour pressure = 1.97 Pa), the exposure via inhalation of citronellyl acetate as a vapour is low. Oral bioavailability of citronellyl acetate is qualitatively indicated by mortalities and clinical findings observed in acute oral toxicity studies in rats and systemic effects observed in murine and rat oral repeated dose toxicity studies.

Concerning metabolism and elimination of citronellyl acetate, the following information is available:

Citronellyl acetate is expected to hydrolyze to citronellol and acetic acid. Citronellyl acetate was reported to be completely hydrolyzed within 2 hours by pancreatin at pH 7.5 (Grundschober, 1977). In animals, hydrolysis of aliphatic esters is catalyzed by classes of enzymes recognized as carboxylesterases or esterases. Terpenoid alcohols formed in the gastrointestinal tract are then rapidly absorbed. Following hydrolysis, citronellol, geraniol ans nerol undergo a complex pattern of alcohol oxidation, omega-oxidation, hydration, selective hydrogenation and subsequent conjugation to form oxygenated polar metabolites, which are rapidly excreted primarily in the urine of animals. Alternately, the corresponding carboxylic acids formed by oxidation of the alcohol function may enter the beta-oxidation pathway and eventually undergo cleavage to yield shorter chain carboxylic acids that are completely metabolized to carbon dioxide. Citronellol, related terpenoid alcohols (geraniol and nerol), and the related aldehydes (geranial and neral) exhibit similar pathways of metabolic detoxication in animals (Revised test plan for Terpenoid Primary Alcohols and Related Esters, The Flavor and Fragrance High Production Volume Consortia - The Terpene Consortium; March 2004).

Based on the information given above, there is no indication for a bioaccumulative potential of citronellyl acetate.