Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 211-492-3 | CAS number: 652-67-5
Endpoint summary
Administrative data
Description of key information
Oral: LD50: > 2000 mg/kg bw for rat
Dermal: LD50: > 2000 mg/kg bw for rat
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
Two toxicological studies were performed with the registered substance, the first one follows both the OECD Guideline 420: acute oral toxicity - fixed dose method and OECD Guideline 401: acute oral toxicity while the second one follows the OECD Guideline 402: acute dermal toxicity, in a certified GLP lab. So the reliability of this data can be ranked as klimisch code 1: reliable without restrictions. On the basis of this analysis, those studies can be chosen as the key studies.
Justification for classification or non-classification
According to Official Journal of the European Union 1272/2008 (CLP) dated December 16th 2008, isosorbide is non-classified in the acute toxicity hazard categories.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
