Registration Dossier
Registration Dossier
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EC number: 211-492-3 | CAS number: 652-67-5
Endpoint summary
Administrative data
Description of key information
Skin irritation/corrosion: not irritating
Eye irritation: not irritating
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Skin irritation/corrosion:
A test of the registered substance was performed on skin irritation/corrosion in vivo according to OECD Guideline 404: acute dermal irritation/corrosionin a certified GLP labs. The study can be ranked as klimisch code 1: reliability without restrictions. The results showed that no toxic effect was found, so the irritative effect of isosorbide can be concluded as no irritating.
Eye irritation:
An in vivo test of the registered substance was performed on eye irritation complying with OECD Guideline 405: eye irritation/corrosion for identifying ocular corrosives and severe irritants. This study is regarded as key study as it can be ranked as klimisch code 1: reliability without restrictions. And the test result showed that isosorbide is not irritating.
Justification for classification or non-classification
Skin irritation/corrosion:
According to Official Journal of the European Union 1272/2008 (CLP) dated December 16th 2008, isosorbide is non-classified in this part.
Eye irritation:
According to Official Journal of the European Union 1272/2008 (CLP) dated December 16th 2008, isosorbide is non-classified in this part.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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