Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 207-050-4 | CAS number: 428-59-1
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- The scientific validity of the (Q)SAR model has been established in accordance with the OECD Principles for (Q)SAR Model Validation. This study was selected as the key study because the information provided for the hazard endpoint is sufficient for the purpose of classification and labelling and/or risk assessment.
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
- Principles of method if other than guideline:
- ECOSAR V1.11
QMRF and QPRF are attached in IUCLID. - GLP compliance:
- not specified
Test material
- Reference substance name:
- Trifluoro(trifluoromethyl)oxirane
- EC Number:
- 207-050-4
- EC Name:
- Trifluoro(trifluoromethyl)oxirane
- Cas Number:
- 428-59-1
- Molecular formula:
- C3F6O
- IUPAC Name:
- 2,2,3-trifluoro-3-(trifluoromethyl)oxirane
Constituent 1
Test organisms
- Test organisms (species):
- Daphnia magna
Results and discussion
Effect concentrations
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 62.73 mg/L
- Nominal / measured:
- estimated
- Basis for effect:
- mortality
- Remarks on result:
- other: predicted using the estimated KOWWIN LogKow of 1.72 (QPRF) and the measured average water solubility of 0.0163 mg/L
Any other information on results incl. tables
Supporting documentation are provided in the attached QPRF and QMRF.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- 48-hour LC50 (daphnia) >62.73 mg/L
This study and the conclusions which are drawn from it fulfil the quality criteria (validity, reliability, repeatability). - Executive summary:
The 48-hour LC50 to daphnia was predicted to be >62.73 mg/L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
