Registration Dossier
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EC number: 203-756-1 | CAS number: 110-31-6
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
LC50 (96 h) > 0.027 mg/L for Oryzias latipes (OECD 203, limit test). No toxicity in the range of water solubility.
Key value for chemical safety assessment
Additional information
There is no data available on the toxicity to fish potential of Amides, C16 and C18-C20 (even numbered, unsaturated), N,N’-ethylenebis. In order to fulfil the standard information requirements set out in Annex VIII, 9.1.3, in accordance with Annex XI, 1.5, of Regulation (EC) No 1907/2006, read-across from a structurally related substance is conducted.
A detailed justification for the grouping of chemicals and read-across is provided in Sections 6.1 and 13.
The short-term toxicity of Amides, C16 and C18-C20 (even numbered, unsaturated), N,N’-ethylenebis to fish was assessed in a read across approach using data from the structural analogue Amides, C16-C18 (even), N,N'-ethylenebis. Three studies investigating the short-term toxicity of the test item to two different fish species were available. A report from the Japanese Ministry of Environment (MOE, 2005) was chosen as key study. This test was conducted according to OECD 203, using Oryzias latipes as test organism, under semi-static conditions. The results from this study show that after 96 h exposure to the test substance no effects were observed up to the highest attainable concentration (0.027 mg/L, limit of solubility). Therefore, the LC50 (96 h) was > 0.027 mg/L, and no toxicity within the range of water solubility was reported. The test from the supporting study (Bürger and Heyner, 2002), was carried out according to OECD 203, using Brachydanio rerio as test organism, under static conditions. Four nominal test concentrations were used, 10, 100, 1000 and 10000 mg/L, and mortality reported after 24, 48, 72 and 96 h. At the end of the test no mortality was observed up to the highest concentration tested. Therefore, the 96 h EC50 was > 10000 mg/L. Additional information was collected from the Japanese Ministry of International Trade and Industry (MITI, 1988), regarding a 48 h test in which Amides, C16-C18 (even), N,N'-ethylenebis did not have an effect on Oryzias latipes, being the 48 h LC50 > 300 mg/L (nominal concentration).
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