Registration Dossier
Registration Dossier
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EC number: 244-600-2 | CAS number: 21829-52-7
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
In vivo and in vitro data are available on dermal absorption of ethanolamine, a minor constituent of the substance, and which the major constituent (carbonic acid, compound with 2-aminoethanol (1:2)) is expected to degrade to under certain conditions. When applied, in ethanol, to human grafted skin and mouse skin approximately 34% of applied radioactivity was recovered in organs/tissues and urine/faeces, and a further 18% was oxidised to [14C]-CO2, indicating dermal absorption over 24h of ca. 52%. A further 18% remained on/in the skin grafts. The registered substance is expected to show a similar absorption rate. On consideration of structure, water solubility, etc. it is expected that the absorption via oral and inhalation exposures will be relatively extensive.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - oral (%):
- 100
- Absorption rate - dermal (%):
- 52
- Absorption rate - inhalation (%):
- 100
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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