Registration Dossier
Registration Dossier
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EC number: 205-642-7 | CAS number: 144-83-2
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1939
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: simialr to the standard test
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 939
Materials and methods
- GLP compliance:
- no
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- sulfapyridine sodium
- IUPAC Name:
- sulfapyridine sodium
- Test material form:
- not specified
- Details on test material:
- No data
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on oral exposure:
- Stomach tube
- Doses:
- 1, 1.5, 2 2000mg/kg bw.
- No. of animals per sex per dose:
- 16 mice per dose
- Control animals:
- not specified
- Statistics:
- No data
Results and discussion
Effect levelsopen allclose all
- Sex:
- not specified
- Dose descriptor:
- other: Mortality
- Effect level:
- 19 other: %
- Based on:
- test mat.
- Sex:
- not specified
- Dose descriptor:
- other: Mortality
- Effect level:
- 25 other: %
- Based on:
- test mat.
- Sex:
- not specified
- Dose descriptor:
- other:
- Effect level:
- 31 other: %
- Based on:
- test mat.
- Clinical signs:
- No data
- Body weight:
- No data
- Gross pathology:
- No data
- Other findings:
- No data
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Based on the test result, the LD50 oral is greater than 2000 mg/kg bw.
- Executive summary:
The Experiments was performed to determine the acute lethal effects of a single dose of the sodium salt. 1000, 15000 and 2000 mg/kg bw were applied to the test mice. after 24 hours, the mortality of 19%, 25% and 31% were observed respectively. Then, we can conclude that the LD50 oral is greater than 2000 mg/kg
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