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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
sub-chronic toxicity: other route
Type of information:
other: publication
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: This is a publication result with a scientific method.

Data source

Reference
Reference Type:
publication
Title:
Unnamed

Materials and methods

GLP compliance:
no
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Sulfapyridine
EC Number:
205-642-7
EC Name:
Sulfapyridine
Cas Number:
144-83-2
Molecular formula:
C11H11N3O2S
IUPAC Name:
4-amino-N-pyridin-2-ylbenzenesulfonamide
Details on test material:
no data

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
The experiment was conducted with a strain freshly cultivated from the cerebrospinal fluid of a fatal case of B. friedländer meningitis secondary to a chronic ethmoiditis due to the same organism.

Administration / exposure

Route of administration:
other: intraäbdominal injection
Vehicle:
other: hot saline solution
Details on exposure:
no data
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
5 days
Frequency of treatment:
twice daily
Doses / concentrations
Remarks:
Doses / Concentrations:
0.2 g sulfapyridine was dissolvctl in 200 cc of hot saline solution giving 0.001 g per cc.
No. of animals per sex per dose:
20 mice: 4 kept as untreated controls, Sixteen of the mice were given 0.160 g sulfapyridine by intraäbdominal injection
Control animals:
yes, concurrent no treatment
Details on study design:
20 mice were inoculated with 0.05 cc of 24-hour broth cultures: 4 kept as untreated controls died in 24 to 72 hours. Sixteen of the mice were given 0.160 g sulfapyridine by intraäbdominal injection immediately after inoculation with a second dose 6 hours later and thereafter twice daily (10 A.M. and 3 P.M.)
for 5 days.

Examinations

Observations and examinations performed and frequency:
no data
Sacrifice and pathology:
no data
Other examinations:
no data
Statistics:
no data

Results and discussion

Results of examinations

Clinical signs:
not specified
Mortality:
not specified
Body weight and weight changes:
not specified
Food consumption and compound intake (if feeding study):
not specified
Food efficiency:
not specified
Water consumption and compound intake (if drinking water study):
not specified
Ophthalmological findings:
not specified
Haematological findings:
not specified
Clinical biochemistry findings:
not specified
Urinalysis findings:
not specified
Behaviour (functional findings):
not specified
Organ weight findings including organ / body weight ratios:
not specified
Gross pathological findings:
not specified
Histopathological findings: non-neoplastic:
not specified
Histopathological findings: neoplastic:
not specified
Details on results:
no data

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion

Conclusions:
Of 16 mice given 0.160 g by intrabdominal injection immediately after inoculation, 6 hours later and thereafter twice daily for 5 days, 4 survived while the lives of 6 were prolonged 1 to 5 days beyond the survival of 4 untreated controls which succumbed in 24 to 72 hours after inoculation.
Executive summary:

The experiment was conducted with a strain freshly cultivated from the cerebrospinal fluid of a fatal case of B. friedländer meningitis secondary to a chronic ethmoiditis due to the same organism. 20 mice were inoculated with 0.05 cc of 24-hour broth cultures: 4 kept as untreated controls died in 24 to 72 hours. Sixteen of the mice were given 0.160 g sulfapyridine by in traiibdominal injection immediately after inoculation with a second dose 6 hours later and thereafter twice daily (10 A.M. and 3 P.M.) for 5 days.Of 16 mice given 0.160 g by intraäbdominal injection immediately after inoculation, 6 hours later and thereafter twice daily for 5 days, 4 survived while the lives of 6 were prolonged 1 to 5 days beyond the survival of 4 untreated controls which succumbed in 24 to 72 hours after inoculation. All treated and untreated mice succumbing gave positive heart-blood cultures. The controls by subcutaneous and intraabdominal injection survived the period of 12 days, when the experiments were terminated.