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Administrative data

Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Study period:
From Mar. 10, 1989 to Mar. 30, 1989
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Well documented, according to accepted guideline, with GLP-like Quality Assurance

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1989
Report date:
1989

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: EEC directive 84/449 C.10
Deviations:
no
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
3-(3-tert-butyl-4-hydroxyphenyl)propionic acid
EC Number:
403-920-4
EC Name:
3-(3-tert-butyl-4-hydroxyphenyl)propionic acid
Cas Number:
107551-67-7
Molecular formula:
C13H18O3
IUPAC Name:
3-(3-tert-butyl-4-hydroxyphenyl)propanoic acid
Details on test material:
- Lot/batch No.: EN.116905.72

Study design

Analytical monitoring:
yes
Details on sampling:
- Sampling intervals for the parent/transformation products: 2.4 hours and 5 days
Buffers:
pH 4:
standard acetate buffer ( 0.1 mole/1 acetic acid + 0.1 mole/1 sodium acetate ) + 15 ml acetic acid per liter.

pH 7:
0.041 mole di-sodium-hydrogenphosphate + 0.028 mole potassium-dihydrogenphosphate per liter.

pH 9:
0.043 mole di-sodium-tetraborate + 0.017 mole potassium-dihydrogenphosphate per liter.
Details on test conditions:
Report states according to EEC guideline 84/449 C.10
Duration of testopen allclose all
Duration:
2.4 h
pH:
4
Temp.:
50 °C
Initial conc. measured:
ca. 0.71 g/L
Duration:
2.4 h
pH:
7
Temp.:
50 °C
Initial conc. measured:
ca. 0.71 g/L
Duration:
2.4 h
pH:
9
Temp.:
50 °C
Initial conc. measured:
ca. 0.71 g/L
Duration:
5 d
pH:
4
Temp.:
50 °C
Initial conc. measured:
ca. 0.71 g/L
Duration:
5 d
pH:
7
Temp.:
50 °C
Initial conc. measured:
ca. 0.71 g/L
Duration:
5 d
pH:
9
Temp.:
50 °C
Initial conc. measured:
ca. 0.71 g/L
Number of replicates:
2 replicates per treatment condition
Positive controls:
not specified
Negative controls:
not specified
Statistical methods:
none reported

Results and discussion

Preliminary study:
The test substance is stable at pH 4, 7, and 9 (less than 10% decomposition after 5 days)
Transformation products:
not measured
Details on hydrolysis and appearance of transformation product(s):
not reported
Details on results:
The test substance is stable at pH 4, 7, and 9 (less than 10% decomposition after 5 days)

Applicant's summary and conclusion