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Administrative data

Workers - Hazard via inhalation route

Systemic effects

Acute/short term exposure
DNEL related information

Local effects

Acute/short term exposure
DNEL related information

Workers - Hazard via dermal route

Systemic effects

Acute/short term exposure
DNEL related information

Workers - Hazard for the eyes

Additional information - workers

Worker: Vacuum Gas Oils, Hydrocracked Gas oils and Distillate fuel oils

 

Effect

Route

DNEL

Dose Descriptor

Modified Dose Descriptor and Assessment Factors

Acute Exposure

Systemic

Dermal

(a)

 

 

Inhalation

4300 mg/m3/ 15 min (for lethality) [aerosol]

1560 mg/m3/4 h (NOAEC based on lethality in acute inhalation study in rats)

Dose descriptor was modified to correct starting point of 16,723 mg/m3/15 min by adjustment for duration of exposure and level of activity. Then a total AF of 7.5 was applied for inter- and intraspecies differences.

Local

Dermal

(a)

 

 

Inhalation

(a)

 

 

Long-Term Exposure

Systemic (b)

Dermal

2.9 mg/kg/8h

30 mg/kg/day

 (NOAEL based on haematological parameters (decreased RBC, haemoglobin, HCT), clinical chemistry values (increased urea nitrogen and cholesterol) parameters and organ weight effects (increased liver weight, decreased thymus weight) in rats)

Dose descriptor was modified to correct starting point of 69.8 mg/kg/day by adjustment for dermal absorption.. Then a total AF of 24 was applied for subchronic to chronic and inter- and intraspecies differences.

Inhalation

68 mg aerosol /m3/8h [aerosol]

125 mg/kg/day

 (NOEL based ondecreased body weight, decreased crown-rump length, decreased litter size and delayed ossification of some skeletal structuresin a rat developmental toxicity study with dermal dosing on GD 0-19)

Dose descriptor was modified to correct starting point of 183.7 mg/m3/8 h by adjustment for dermal absorption, extrapolation from dermal to inhalation route, and ventilation in workers. Then a total AF of 7.5 was applied for inter- and intraspecies and remaining differences.

Local

Dermal

(a) for 13-wk exposures and

(c) for chronic exposures (dermal carcinogen)

 

 

Inhalation

(a)

 

 

a) No hazard identified for this route (data available)

b) Long-term systemic effects include non-reproductive effects and developmental/reproductive effects. Lowest DNEL is shown.

c) No-threshold effect and/or no dose-response information available

General Population - Hazard via inhalation route

Systemic effects

Acute/short term exposure
DNEL related information

Local effects

Acute/short term exposure
DNEL related information

General Population - Hazard via dermal route

Systemic effects

Acute/short term exposure
DNEL related information

General Population - Hazard via oral route

Systemic effects

Acute/short term exposure
DNEL related information

General Population - Hazard for the eyes

Additional information - General Population

General Population HC_Dist_Vacuum Gas Oils

  

 

Effect

Route

DNEL

Dose Descriptor

Modified Dose Descriptor and Assessment Factors

Acute Exposure

Systemic

Dermal

(a)

 

 

Inhalation

2600 mg/m3/ 15 min (for lethality) [aerosol]

1560 mg/m3/4 h (NOAEC based on lethality in acute inhalation study in rats)

Dose descriptor was modified to correct starting point of 16,723 mg/m3/15 min by adjustment for duration of exposure and level of activity. Then a total AF of 7.5 was applied for inter- and intraspecies differences.

Local

Dermal

(a)

 

 

Inhalation

(a)

 

 

Long-Term Exposure

Systemic (b)

Dermal

1.3 mg/kg/24h

30 mg/kg/day

 (NOAEL based on haematological parameters (decreased RBC, haemoglobin, HCT), clinical chemistry values (increased urea nitrogen and cholesterol) parameters and organ weight effects (increased liver weight, decreased thymus weight) in rats)

Dose descriptor was modified to correct starting point of 69.8 mg/kg/day by adjustment for dermal absorption.. Then a total AF of 24 was applied for subchronic to chronic and inter- and intraspecies differences.

Inhalation

20 mg aerosol /m3/24h [aerosol]

125 mg/kg/day

 (NOEL based ondecreased body weight, decreased crown-rump length, decreased litter size and delayed ossification of some skeletal structuresin a rat developmental toxicity study with dermal dosing on GD 0-19)

Dose descriptor was modified to correct starting point of 144 mg/m3/24h by adjustment for dermal absorption, extrapolation from dermal to inhalation route, and ventilation in general population. Then a total AF of 7.5 was applied for inter- and intraspecies and remaining differences.

Local

Dermal

(a) for 13-wk exposures and

(c) for chronic exposures (dermal carcinogen)

 

 

Inhalation

(a)

 

 

a) No hazard identified for this route (data available)

b) Long-term systemic effects include non-reproductive effects and developmental/reproductive effects. Lowest DNEL is shown.

c) No-threshold effect and/or no dose-response information available

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