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Toxicological information

Genetic toxicity: in vitro

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Administrative data

Endpoint:
in vitro cytogenicity / chromosome aberration study in mammalian cells
Remarks:
Type of genotoxicity: chromosome aberration
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Study by GLP lab.

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed
Year:
1986
Report date:
1986

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Annex V
GLP compliance:
yes
Type of assay:
other: In vitro mammalian cytogenicity (B10)

Test material

Constituent 1
Chemical structure
Reference substance name:
Butyl (dialkyloxy(dibutoxyphosphoryloxy))titanium(trialkyloxy)titanium phosphate
EC Number:
401-100-0
EC Name:
Butyl (dialkyloxy(dibutoxyphosphoryloxy))titanium(trialkyloxy)titanium phosphate
Cas Number:
109037-78-7
Molecular formula:
C24 H46 O10 P2 Ti2 (typical - see 'Remarks' below.
IUPAC Name:
butyl (dialkyloxy(dibutoxyphosphoryloxy))titanium(trialkyloxy)titanium phosphate

Method

Species / strain
Species / strain / cell type:
mammalian cell line, other: Human lymphocytes

Results and discussion

Any other information on results incl. tables

Data supplied in response to Inquiry 06 -0000024087 -70 -0000

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information):
negative with metabolic activation
negative without metabolic activation