Registration Dossier
Registration Dossier
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EC number: 608-291-1 | CAS number: 2890-61-1
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study according EU/OECD guideline.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 1-methylcyclohexane-1-carbonyl chloride
- EC Number:
- 608-291-1
- Cas Number:
- 2890-61-1
- Molecular formula:
- C8H13ClO
- IUPAC Name:
- 1-methylcyclohexane-1-carbonyl chloride
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Doses:
- 200 and 2.000 mg/kg body weight (bw)
- No. of animals per sex per dose:
- 5 male and 5 female rats
- Control animals:
- no
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 200 - < 2 000 mg/kg bw
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 200 - < 2 000 mg/kg bw
- Mortality:
- At a dose of 2000 mg/kg b.w. all animals died.
A dose of 200 mg/kg b.w. was tolerated by both sexes without clinical signs and mortalities. - Clinical signs:
- other: At a dose of 2000 mg/kg b.w. the following clinical signs were observed: piloerection, labored breathing, decreased motility, atony, staggering gait, decreased reactivity, poor resp. no reflexes. The signs observed occurred shortly after administration.
- Gross pathology:
- In animals which died during the post-treatment observation
period the following changes were detected (nomenclature
according to path-data system):
lung: change in contents, foamy
Stomach: compound, yellow, severely, hemorrhage, clotted blood,
severely
Intestine: compound, yellow
Liver: discoloration, dark red
In animals sacrificed at the end of the post-treatment observation
period no changes were detected.
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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