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Diss Factsheets
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EC number: 608-291-1 | CAS number: 2890-61-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study according EU/OECD guideline.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 998
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 1-methylcyclohexane-1-carbonyl chloride
- EC Number:
- 608-291-1
- Cas Number:
- 2890-61-1
- Molecular formula:
- C8H13ClO
- IUPAC Name:
- 1-methylcyclohexane-1-carbonyl chloride
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- nose only
- Vehicle:
- clean air
- Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- nominal: 0, 1000, 2000, 3000, 4000 and 8000 mg/m³
analytical: 494.1; 1286.4; 2315.8 and 3609.4 mg/m³ - No. of animals per sex per dose:
- Five male and five female rats
- Control animals:
- yes
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- 1 305 mg/m³ air
- Based on:
- act. ingr.
- 95% CL:
- 781 - 2 180
- Exp. duration:
- 4 h
- Remarks on result:
- other: inhalation (vapour)
- Sex:
- female
- Dose descriptor:
- LC50
- Effect level:
- ca. 3 609 mg/m³ air
- Based on:
- act. ingr.
- Exp. duration:
- 4 h
- Remarks on result:
- other: inhalation (vapour)
- Sex:
- male/female
- Dose descriptor:
- other: NO(A)EL
- Effect level:
- < 494.1 mg/m³ air
- Based on:
- act. ingr.
- Mortality:
- Mortality occurred on the exposure day or up to the first postexposure day.
All animals of the highest dose group died.
4 males of the 4000 mg/m³ group and 3 males of the 3000 mg/m³ group died. - Clinical signs:
- other: 1000 mg/m³: All rats tolerated the exposure without specific signs. 2000, 3000, 4000 and 8000 mg/m³: Piloerection, ungroomed hair-coat, pallor, reduced motility, limp blepharospasm, bradypnea, labored and unregular breathing pattern, nostrils reddened, n
- Gross pathology:
- Animals sacrificed at the end of the observation period: In rats exposed to the test compound a conclusive, concentration-dependent increased incidence of macroscopic findings could not be ascertained. Therefore, the focal discolorations of organs observed in some groups are not considered to be causally related to the exposure to the test substance. Findings such as mild discoloration's of lung and other parenchymatous organs are often observed in control animals euthanized with pentobarbital. Therefore, the lung findings observed in rats of group 2 do not appear to exceed to spontaneously occurring incidence.
Animals that died intercurrentlv (most salient findings): Lungs: less collapsed, edematous, and hydrothorax.
Applicant's summary and conclusion
- Interpretation of results:
- toxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Executive summary:
LC50 inhalation (vapour, 4 hr) : 1305 mg/m3 air
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