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Registration Dossier
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EC number: 905-276-4 | CAS number: -
Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- repeated dose toxicity: dermal
- Remarks:
- other: migrated dataset
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: special study and only one dose used, no dose-response relationship can be derived and thus no NOAEL or LOAEL can be deduced.
Data source
Reference
- Title:
- No information
- Author:
- Shelley WB (1974) p-Cresol: Cause of ink-induced hair depigmentation in mice. British Journal of Dermatology 90: 9-174
Materials and methods
- Principles of method if other than guideline:
- Method: other: see freetext RM
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Automatically generated during migration to IUCLID 6, no data available
- IUPAC Name:
- Automatically generated during migration to IUCLID 6, no data available
- Details on test material:
- IUCLID4 Test substance: other TS: p-cresol, purity not noted
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- C57BL
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- migrated dataset
Administration / exposure
- Details on exposure:
- Route of Administration: dermal
- Details on analytical verification of doses or concentrations:
- migrated dataset
- Duration of treatment / exposure:
- 6 weeks
- Frequency of treatment:
- 3x/week
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.5 % in acetone
Basis:
- No. of animals per sex per dose:
- migrated dataset
- Control animals:
- other: no data specified
- Details on study design:
- Post-exposure period: 6 months
- Positive control:
- migrated dataset
Examinations
- Observations and examinations performed and frequency:
- migrated dataset
- Sacrifice and pathology:
- migrated dataset
- Other examinations:
- migrated dataset
- Statistics:
- migrated dataset
Results and discussion
Results of examinations
- Details on results:
- migrated dataset
Effect levels
open allclose all
- Dose descriptor:
- NOAEL
- Effect level:
- < 0.5
- Sex:
- male
- Dose descriptor:
- LOAEL
- Effect level:
- <= 0.5
- Sex:
- male
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
RS-Freetext:
Topical application caused depigmentation of the hair and
pigmented epidermis, especially of the tail. Large amounts
of p-cresol were lethal and had a local caustic,
erosive effect.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
