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EC number: 905-276-4 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- repeated dose toxicity: dermal
- Remarks:
- other: migrated dataset
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: special study and only one dose used, no dose-response relationship can be derived and thus no NOAEL or LOAEL can be deduced.
Data source
Reference
- Title:
- No information
- Author:
- Shelley WB (1974) p-Cresol: Cause of ink-induced hair depigmentation in mice. British Journal of Dermatology 90: 9-174
Materials and methods
- Principles of method if other than guideline:
- Method: other: see freetext RM
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Automatically generated during migration to IUCLID 6, no data available
- IUPAC Name:
- Automatically generated during migration to IUCLID 6, no data available
- Details on test material:
- IUCLID4 Test substance: other TS: p-cresol, purity not noted
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- C57BL
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- migrated dataset
Administration / exposure
- Details on exposure:
- Route of Administration: dermal
- Details on analytical verification of doses or concentrations:
- migrated dataset
- Duration of treatment / exposure:
- 6 weeks
- Frequency of treatment:
- 3x/week
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.5 % in acetone
Basis:
- No. of animals per sex per dose:
- migrated dataset
- Control animals:
- other: no data specified
- Details on study design:
- Post-exposure period: 6 months
- Positive control:
- migrated dataset
Examinations
- Observations and examinations performed and frequency:
- migrated dataset
- Sacrifice and pathology:
- migrated dataset
- Other examinations:
- migrated dataset
- Statistics:
- migrated dataset
Results and discussion
Results of examinations
- Details on results:
- migrated dataset
Effect levels
open allclose all
- Dose descriptor:
- NOAEL
- Effect level:
- < 0.5
- Sex:
- male
- Dose descriptor:
- LOAEL
- Effect level:
- <= 0.5
- Sex:
- male
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
RS-Freetext:
Topical application caused depigmentation of the hair and
pigmented epidermis, especially of the tail. Large amounts
of p-cresol were lethal and had a local caustic,
erosive effect.
Applicant's summary and conclusion
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