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Diss Factsheets

Administrative data

surface tension
Type of information:
experimental study
Adequacy of study:
key study
Study period:
14 February 2006 - 8 March 2006
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: The study was conducted in GLP compliance and in accordance with several internationally established guidelines (OECD, EEC, EPA guidelines, see below).

Data source

Reference Type:
study report
Report date:

Materials and methods

Test guidelineopen allclose all
according to guideline
OECD Guideline 115 (Surface Tension of Aqueous Solutions)
according to guideline
EU Method A.5 (Surface Tension)
GLP compliance:
yes (incl. QA statement)
Type of method:
OECD harmonised ring method

Test material

Constituent 1
Chemical structure
Reference substance name:
EC Number:
EC Name:
Cas Number:
Molecular formula:
C33 H30 N4 O2 x HCl
4’-(2-Propyl-4-methyl-6-(1-methylbenzimidazolyl-2-yl)-benzimidazol-1-ylmethyl)biphenyl-2-carbonsäure Hydrochlorid
Test material form:
other: solid
Details on test material:
- Name of test material (as cited in study report): BIBR 277 CL
- Molecular formula (if other than submission substance): C33H30N4O2*HCl
- Molecular weight (if other than submission substance): 514.6 + 36.5 g/mol
- Structural formula attached as image file (if other than submission substance): see reference substance
- Physical state: solid; sligh grey
- Analytical purity: 99.8 %
- Purity test date: 17. october 2005
- Lot/batch No.: 9
- Expiration date of the lot/batch: april 2006
- Storage condition of test material: at room temperature, dark and dry

Results and discussion

Surface tension
Surface tension:
70.9 mN/m
20 °C
96.4 mg/L

Any other information on results incl. tables

Table 1 Time Dependence of the surface tension after transferring the solution to the measurement vessel

 Surface tension [mN/m]  Equilibrium time [sec]
 9  14
 29  30
 47.5  44
 58  60
 69.5  79
 70.9  82
 70.9  90

Equilibrium time = time after transferring the solution to the vessel until measuring the surface tension of the soluion

Table 2: Measured surface tension values and equilibrium times

 Surface tension (mN/m)  Equilibrium time [sec]
 70.9  82
 70.8  82
 70.9  84
 70.9  83
 70.8  82

Equilibrium time = time after transferring the soltion to the vessel until measuring the surface tension of the solution

Applicant's summary and conclusion

A surface tension value of 70.9 mN/m at 20°C of a 96.4 mg/L was obtained for the test item in a reliable study conducted according to an appropriate OECD test method. According to EC testing directive 440/2008 A.5 the test item is not considered to be surface active.