4’-(2-Propyl-4-methyl-6-(1-methylbenzimidazolyl-2-yl)-benzimidazol-1-ylmethyl)biphenyl-2-carbonsäure Hydrochlorid

Surface tension

Administrative data

Endpoint:

surface tension

Type of information:

experimental study

Adequacy of study:

key study

Study period:

14 February 2006 - 8 March 2006

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: The study was conducted in GLP compliance and in accordance with several internationally established guidelines (OECD, EEC, EPA guidelines, see below).

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2006

Report date:

2006

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

OECD Guideline 115 (Surface Tension of Aqueous Solutions)

Test guideline 2

Qualifier:

according to guideline

Guideline:

EU Method A.5 (Surface Tension)

GLP compliance:

yes (incl. QA statement)

Type of method:

OECD harmonised ring method

Test material

Test material information

Constituent 1

Reference substance name:

-

EC Number:

485-140-4

EC Name:

-

Cas Number:

515815-48-2

Molecular formula:

C33 H30 N4 O2 x HCl

IUPAC Name:

4’-(2-Propyl-4-methyl-6-(1-methylbenzimidazolyl-2-yl)-benzimidazol-1-ylmethyl)biphenyl-2-carbonsäure Hydrochlorid

Test material form:

other: solid

Details on test material:

- Name of test material (as cited in study report): BIBR 277 CL
- Molecular formula (if other than submission substance): C33H30N4O2*HCl
- Molecular weight (if other than submission substance): 514.6 + 36.5 g/mol
- Structural formula attached as image file (if other than submission substance): see reference substance
- Physical state: solid; sligh grey
- Analytical purity: 99.8 %
- Purity test date: 17. october 2005
- Lot/batch No.: 9
- Expiration date of the lot/batch: april 2006
- Storage condition of test material: at room temperature, dark and dry

Results and discussion

Surface tension

Surface tension:

70.9 mN/m

Temp.:

20 °C

Conc.:

96.4 mg/L

Any other information on results incl. tables

Table 1 Time Dependence of the surface tension after transferring the solution to the measurement vessel

Surface tension [mN/m]	Equilibrium time [sec]
9	14
29	30
47.5	44
58	60
69.5	79
70.9	82
70.9	90

Equilibrium time = time after transferring the solution to the vessel until measuring the surface tension of the soluion

Table 2: Measured surface tension values and equilibrium times

Surface tension (mN/m)	Equilibrium time [sec]
70.9	82
70.8	82
70.9	84
70.9	83
70.8	82

Equilibrium time = time after transferring the soltion to the vessel until measuring the surface tension of the solution

Applicant's summary and conclusion

Conclusions:

A surface tension value of 70.9 mN/m at 20°C of a 96.4 mg/L was obtained for the test item in a reliable study conducted according to an appropriate OECD test method. According to EC testing directive 440/2008 A.5 the test item is not considered to be surface active.