Registration Dossier

Diss Factsheets

Administrative data

Description of key information

Methyl 3-α,7-α-diacetoxy-12-α-hydroxy-5-β-cholan-24-oate resulted not irritating to the skin and the eyes. 

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

No experimental results with laboratory animals are available, but the in silico study is well documented and results are calculated according to validated prediction tools.

Regarding skin irritation, tools predicted that methyl 3-α,7-α-diacetoxy-12-α-hydroxy-5-β-cholan-24-oate is negative.

Regarding eye irritation, tools predicted methyl 3-α,7-α-diacetoxy-12-α-hydroxy-5-β-cholan-24-oate negative.


Justification for selection of skin irritation / corrosion endpoint:
No experimental results with laboratory animals are available, but the in silico study is well documented and results are calculated according to validated prediction tools.

Justification for selection of eye irritation endpoint:
No experimental results with laboratory animals are available, but the in silico study is well documented and results are calculated according to validated prediction tools.

Justification for classification or non-classification

According to the results of the QSAR predictions methyl 3-α,7-α-diacetoxy-12-α-hydroxy-5-β-cholan-24-oate is classified neither for skin irritation/corrosion nor for eye irritation according to Regulation 1272/2008/EC.