Registration Dossier
Registration Dossier
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EC number: 457-940-3 | CAS number: 183065-68-1
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- October- December 2003
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted accroding to OECD and GLP guidelines
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 004
- Report date:
- 2004
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
- GLP compliance:
- yes (incl. QA statement)
- Type of study:
- mouse local lymph node assay (LLNA)
Test material
- Reference substance name:
- 4-bromo-2,6-difluorobenzoic acid
- EC Number:
- 457-940-3
- EC Name:
- 4-bromo-2,6-difluorobenzoic acid
- Cas Number:
- 183065-68-1
- Molecular formula:
- Hill formula: C7H3BrF2O2 CAS formula: C7H3BrF2O2
- IUPAC Name:
- 4-bromo-2,6-difluorobenzoic acid
Constituent 1
Results and discussion
In vivo (LLNA)
Results
- Parameter:
- SI
- Remarks on result:
- other: The Stimulation indices were 0.7, 0.6, and 0.7 for the tested concentrations 25, 10, and 5 %, respectively.
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information
- Executive summary:
The skin sensitizing potential of 4-Bromo-2,6-difluorobenzoic acid was tested accroding to OECD 429. The Stimulation indices were 0.7, 0.6, and 0.7 for the tested concentrations 25, 10, and 5 %, respectively. Thus, 4-Bromo-2,6-difluorobenzoic acid is not considered as a skin sensitizer
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