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Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
22 March 2004 to 04 April 2004
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
Version / remarks:
European Economic Community (EEC), EEC directive 92/69 EEC, Part A, Methods for the determination of physico-chemical properties, A.4 'Vapour pressure", EEC Publication No. L3B3, December 1992.
Deviations:
no
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Version / remarks:
Organisation for Economic Co-operation and Development (OECD), OECD guidelines for Testing chemicals, Guideline No.104: 'Vapour pressure curve", July 27, 1995.
Deviations:
no
GLP compliance:
yes
Type of method:
static method
Specific details on test material used for the study:
No further details specified in the study report.
Key result
Temp.:
20 °C
Vapour pressure:
0.22 Pa
Key result
Temp.:
20 °C
Vapour pressure:
0.002 mm Hg

The first measurement of the first series was a deviating value due to system instability and was not taken into account for the calculations. The results of the vapour pressure calculations are summarised in Table 1.

 

Table 1: Vapour pressure of Hatcol 5150 at 3 different temperatures

Measurement

Temperature

Mean vapour pressure ± 2 x calculated error [pa]

[°C]

[K]

p

In p

419

22 – 32

3347

37.93

32.76

25.96

311.08

305.91

299.11

1.156 ± 0.038

0.747 ± 0.005

0.392 ± 0.005

0.145 ± 0.032

-0.292 ± 0.007

-0.938 ± 0.014

 

Fitting the data using the least squares method gives a value of 0.165 Pa for the vapour pressure of the test substance at 20 °C. The error for the vapour pressure (p) calculated from the fit was 5.0 %. The deviation between each of the three data points and the fit was ≤ 2.0 %.

The error made in estimating the mean vapour pressure per temperature series was ≤ 1.1 %.

Taking all these errors into account, a value of 0.01 Pa (i.e. 6.0 %) was found to be reasonable for the uncertainty in the calculated vapour pressure at 20 °C.

 

According to the OECD guideline, the recommended range for the Static method is: 10 up to 105 Pa. However, when using a capacitance manometer, the Static method can be used below 10-1Pa (according to guideline's paragraph 'Apparatus'). This study was performed using a capacitance manometer with a measurement range of 6x10-3 Pa - 2x105 Pa. The vapour pressures measured for Hatcol 5150 at the three test temperatures were all between 0.3 and 1.1 Pa.

All sensors, thermometers and pressure sensor heads were calibrated over the ranges used in the experiments. Pressure sensor heads were calibrated from high vacuum (<< 10-5 Pa) to be read as "0”-value up to 1 Pa. The thermometers were calibrated in the measurement range used for testing.

The measured vapour pressures and their natural logarithms are summarised below and are expressed in Pa. The values given are rounded values.

 

37.93˚C (311.08 K)

32.76˚C (305.91 K)

25.96˚C (299.11 K)

Nr

P

Ln P

Nr

P

Ln P

Nr

P

Ln P

1

1.34

0.29*

20

0.724

-0.32*

33

0.389

-0.94

2

1.25

0.22*

21

0.732

-0.31*

34

0.398

-0.92

3

1.22

0.20*

22

0.747

-0.29

35

0.398

-0.92

4

1.17

0.16

23

0.747

-0.29

36

0.395

-0.93

5

1.18

0.16

24

0.746

-0.29

37

0.394

-0.93

6

1.15

0.14

25

0.754

-0.28

38

0.391

-0.94

7

1.13

0.13

26

0.748

-0.29

39

0.390

-0.94

8

1.13

0.12

27

0.739

-0.30

40

0.390

-0.94

9

1.16

0.15

28

0.745

-0.29

41

0.388

-0.95

10

1.16

0.15

29

0.747

-0.29

42

0.390

-0.94

11

1.12

0.11

30

0.751

-0.29

43

0.388

-0.95

12

1.12

0.12

31

0.744

-0.30

44

0.392

-0.94

13

1.17

0.16

32

0.748

-0.29

45

0.385

-0.95

14

1.19

0.17

 

 

 

46

0.392

-0.94

15

1.18

0.16

 

 

 

47

0.390

-0.94

16

1.15

0.14

 

 

 

 

 

 

17

1.19

0.18

 

 

 

 

 

 

18

1.16

0.15

 

 

 

 

 

 

19

1.14

0.13

 

 

 

 

 

 

* system instability. The (Ln) p value obtained during this measurement was not used for the calculations.

Conclusions:
The Static Technique was used for the determination of the vapour pressure at 20 °C.
Hatcol 5127 p(20°C) = 0.22 ± 0.01 Pa = (1.66 ±. 008)e-3 mm Hg
Executive summary:

The determination of the vapour pressure was performed in accordance with the following guidelines:

European Economic Community (EEC), EEC directive 92/69 EEC, Part A, Methods for the determination of physico-chemical properties, A.4 'Vapour pressure", EEC Publication No. L333, December 1992.

Organisation for Economic Co-operation and Development (OECD), OECD guidelines for Testing chemicals, Guideline No.104: 'Vapour pressure curve", July 27, 1995.

 

The Static Technique was used for the determination of the vapour pressure at 20 °C.

Hatcol 5127

p(20°C) = 0.22 ± 0.01 Pa = (1.66 ±. 008)e-3 mm Hg

 

According to the OECD guideline, the recommended range for the Static method is: 10 up to 105Pa. However, when using a capacitance manometer, the Static method can be used below 10-1Pa (according to guideline's paragraph 'Apparatus'). This study was performed using a capacitance manometer with a measurement range of 6x10-3Pa - 2x105Pa. The vapour pressures measured for Hatcol 5127 at the three test temperatures were all between 0.3 and 1.1 Pa.

All sensors, thermometers and pressure sensor heads were calibrated over the ranges used in the experiments. Pressure sensor heads were calibrated from high vacuum (<< 10-5Pa) to be read as "0”-value up to 1 Pa. The thermometers were calibrated in the measurement range used for testing.

Description of key information

p(20 °C) = 0.22 ± 0.01 Pa = (1.66 ±. 008)x10 -3mm Hg

Key value for chemical safety assessment

Vapour pressure:
0.22 Pa
at the temperature of:
20 °C

Additional information

The Static Technique was used for the determination of the vapour pressure at 20 °C.

Hatcol 5150

p(20 °C) = 0.22 ± 0.01 Pa = (1.66±. 008)x10-3mm Hg

 

 

According to the OECD guideline, the recommended range for the Static method is: 10 up to 105Pa. However, when using a capacitance manometer, the Static method can be used below 10-1Pa (according to guideline's paragraph 'Apparatus'). This study was performed using a capacitance manometer with a measurement range of 6x10-3Pa - 2x105Pa. The vapour pressures measured for Hatcol 5127 at the three test temperatures were all between 0.3 and 1.1 Pa.

All sensors, thermometers and pressure sensor heads were calibrated over the ranges used in the experiments. Pressure sensor heads were calibrated from high vacuum (<< 10-5Pa) to be read as "0”-value up to 1 Pa. The thermometers were calibrated in the measurement range used for testing.