Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 473-450-2 | CAS number: -
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- other: statement
- Adequacy of study:
- key study
- Study period:
- 27 February 2006 - 20 April 2006
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: OECD and EC guidelines were followed. However since for this test substance no partition can be determined, a statement was issued.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 006
- Report date:
- 2006
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Deviations:
- no
- Principles of method if other than guideline:
- all common methods to determine the Kow of the substance were considered and their usefulness/applicability was argued, coming to the conclusion that none of the methods was suitable to determine the Kow of the substance; therefore a statement was issued
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- other: statement
Test material
- Reference substance name:
- No.338 RED
- IUPAC Name:
- No.338 RED
- Details on test material:
- Description: red powder
Batch number: 50670
Constituent 1
Results and discussion
Any other information on results incl. tables
Shake-flask method:
Testing was not possible by the shake-flask method as the test material was determined visually to be essentially insoluble in both n-octanol and water.
HPLC method:
The HPLC method was not valid as no molecular forms of the test material could be obtained due to either the presence of a strong acid functional group or zwitterion properties.
Estimation/calculation method:
Finally, alternative computer estimation methods were considered to potentially underestimate the partition coefficient of the test material components as a high number of nitrogen and oxygen atoms are typically representative of hydrophilic functional groups.
In conclusion, no value of the partition coefficient could be determined by the shake-flask method. In addition, the alternative HPLC or computer estimation methods were also proven to be invalid for the three components present in the test material.
Applicant's summary and conclusion
- Conclusions:
- The shake-flask method, HPLC method and estimation/calculation methods are not applicable for the determination of the partition coefficient of the test substance, due to its low solubility in both n-octanol and water, and due to the structure and composition of the test material. Therefore no value of the partition coefficient can be determined for the test substance.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
