Registration Dossier
Registration Dossier
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EC number: 478-130-6 | CAS number: 50940-49-3
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
MAES, 2-(acryloyloxy)ethyl hydrogen succinate, is readily hydrolized and metabolites are excreted in urine or as carbondioxice by respiration.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
MAES is 2-(acryloyloxy)ethyl hydrogen succinate, molecular 216. It is an involatile liquid at room temperature, freezing at -17°C and decomposing at 139°C. The substance is soluble in water (solubility 162 g/L). It has a log Pow of 0.254. It is very slowly hydrolysed in acid (half life 295 d at pH 4 and 25°C), but relatively readily hydrolysed in alkali (half life 46.5 h at pH 9 and 25°C).
The toxicity information indicates that the substance is harmful if swallowed. Although there was no evidence of corrosivity in the TER test, the substance was corrosive in a conventional skin sensitisation assay. In the 28 day repeated dose study effects were seen in the stomach (acanthosis/hyperkeratosis) at 150 and 300 mg/kg bw/d and, in males at all dose levels (15, 150 and 1000 mg/kg bw/d) , duodenum (mucosal hypertrophy). Systemic effects were only seen at 300 mg/kg bw/d, suggesting they were secondary to the effects at the site of administration (the stomach) due to the corrosive nature of the administered substance and/or hydrolysis products, and in the duodenum of males, possibly due to the corrosivity being enhanced as hydrolysis is speeded as the pH of the gastro-intestinal tract content is raised. The substance was negative in a bacterial reverse mutation assay and a mouse micronucleus assay for genotoxicity, but positive in a chromosomal aberration study in vitro.
One possible hydrolysis product may be acrylic acid. Acrylic acid is also known to be harmful if swallowed and corrosive and is listed on Annex 1 to Directive 67/548/EEC as harmful - R20/21/22 (harmful if swallowed, in contract with skin and by inhalation) and corrosive - R35 (causes severe burns).
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