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EC number: 478-130-6
CAS number: 50940-49-3
The acute oral median lethal dose (LD50) of the test material in the
female Sprague-Dawley CD strain rat was approximately 775 mg/kg
bodyweight with no mortality at 300 mg/kg
bodyweight (LC0) and 100% mortality at 2000 mg/kg bodyweight (LC100).
Acute toxicity inhalation study is considered inappropriate as there is
likely to be no human exposure to aerosols, particles or droplets of an
Acute dermal toxicity was deemed inappropriate as the test material has
already been classified as as corrosive to rabbit skin.
Acute Oral Toxicity. A study
was performed to assess the acute oral toxicity of the test material
following a single oral administration in the Sprague-Dawley CD strain
rat. The method was designed to meet the requirements of the following:
- OECD Guidelines for the Testing of Chemicals No. 423
"Acute Oral Toxicity - Acute Toxic Class Method" (adopted 17 December
- Method B1 tris Acute Toxicity (Oral) of Commission
The acute oral median lethal dose (LD50) of the test
material in the female Sprague-Dawley CD strain rat was approximately
775 mg/kg bodyweight.
A repeated dose rangefinder showed no mortality exposing
rats to 750 mg/kg bw/day for 14 days.
Acute Toxicity Inhalation:
In accordance with Column 2 Adaptation, Annex VII (8.5.2) of REACH
REgulation 1272/2008, testing by inhalation route is inappropriate since
the substance is considered not sufficiently volatile. Therefore, there
is likely to be no human exposure to aerosols, particles or droplets of
an inhalable size.
Acute Toxicity Dermal:
In accordance with REACH Regulation, Annex VIII (8.1.1)
of REACH Regulation 1272/2008, the study does not need to be conducted
if the substance is classified as as corrosive to the skin or as a skin
irritant. The test material has already been classified as as corrosive
to rabbit skin.
The acute oral median lethal dose (LD50) of
the test material in the female Sprague-Dawley CD strain rat was above
300 mg/kg bodyweight (LC0) but below 2000 mg/kg bodyweight (LC100).
According to CLP, classification is acute oral
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