Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (sensitising)
Additional information:

The GPMT test yielded a clear positive result for undiluted NIKKOL VC-IP.

The human patch tests (included in section 7.10.4) were performed with low concentrations (5 and 10%), therefore the results are not considered applicable for the undiluted substance. Systemic exposure to the substance may not have occurred; volunteers might not sufficiently be induced by the test substance, limiting the acceptability of these studies for evaluation of the skin sensitizing properties of NIKKOL VC-IP. These data might be more appropriate for evaluation of the skin sensitizing potential of end-use products.

Therefore, the available negative human patch tests cannot nullify the positive GPMT test. It should therefore be concluded that NIKKOL VC-IP needs classification with H317.

Migrated from Short description of key information:
In a GPMT test performed according to OECD 406 NIKKOL VC-IP was a skin sensitizer.

Justification for classification or non-classification

Based on the available information, NIKKOL VC-IP is classified according to CLP 1272/2008.