Registration Dossier
Registration Dossier
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EC number: 244-787-0 | CAS number: 22113-87-7
Endpoint summary
Administrative data
Description of key information
Skin irritation results:
- corrosive
Eye irritation results:
-highly irritating (secondary sources)
- irritating (IUCLID)
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Methylamine in aqueous solution is the main substance tested in the overall data presented, and it can be assumed that compared to nitrate, which is a common anionic compound, methylamine is the most toxic substance regarding skin and eyes. The results showing the corrosiveness and the highly irritating potential of methylamine for respectively skin and eyes should therefore be sufficient.
Concerning theses results, they correspond either to methylamine liquified gas (equivalent to a 100% solution) or methylamine aqueous 40%, which is less concentrated than the submitted substance. Consequently methylammonium nitrate 86% is expected to present at least the same results.
Effects on skin irritation/corrosion: corrosive
Effects on eye irritation: highly irritating
Effect level: empty Endpoint conclusion: Adverse effect observed
Justification for classification or non-classification
1) Skin irritation: Methylamine is clearly defined as skin corrosive, so the same definition will apply to methylamine nitrate. The weight of evidence approach allows to classify methylamine nitrate as skin corrosive Category 1, as the observed effects seem to be serious and irreversible damages to the skin. Moreover in one study the effects occur immediately after the exposition, leading to skin damage in a few minutes and necrosis within 48 hours. This means the substance can be classified in the Corrosive subcategory 1A.
2) Eye irritation: Methylamine nitrate should be classified in Category 1 (irreversible effects on the eye/serious damage to eyes), for 2 reasons: first, the substance is classified as skin corrosive Category 1, meaning that serious damage to eyes is implicit; then, the results for methylamine 40% solution indicate precisely that the substance belongs to he EC classification "risk of serious damage to eyes".
3) Respiratory irritation: there was no data available on this particular endpoint.
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