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EC number: 215-325-5 | CAS number: 1321-74-0
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- data is from authoritative databases
Data source
Referenceopen allclose all
- Reference Type:
- other: authoritative database
- Title:
- HSDB for the CAS: 1321-74-0
- Author:
- US National Library of Medicine
- Year:
- 2 009
- Bibliographic source:
- Hazardous substance Databank, US National Library of Medicine, last updated 2009
- Reference Type:
- other: authoritative database
- Title:
- GESTIS for the CAS: 1321-74-0
- Author:
- IFA GESTIS
- Year:
- 2 018
- Bibliographic source:
- Institut für Arbeitsschutz der Deutschen Gesetzlichen Unfallversicherung (IFA) GESTIS-database on hazardous substance, 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- To assess the ocular irritation potential of divinylbenzene in rabbits
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Divinylbenzene
- EC Number:
- 215-325-5
- EC Name:
- Divinylbenzene
- Cas Number:
- 1321-74-0
- Molecular formula:
- C10H10
- IUPAC Name:
- 1,2-di(ethenyl)benzene
- Test material form:
- liquid
- Details on test material:
- - Name of test material : 1,2-di(ethenyl)benzene- Common Name : Divinylbenzene- Molecular formula : C10H10- Molecular weight : 131.1969 g/mol- Smiles notation : C=CC1=CC=CC=C1C=C- InChl : MYRTYDVEIRVNKP-UHFFFAOYSA-N- Substance type: Organic- Physical state: Liquid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Divinylbenzene- Molecular formula: C10H10- Molecular weight: 131.1969 g/mol- Smiles notation: C=CC1=CC=CC=C1C=C- InChl: 1S/C10H10/c1-3-9-7-5-6-8-10(9)4-2/h3-8H,1-2H2- Substance type: Organic- Physical state: Liquid
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 0.1 ml
- Duration of treatment / exposure:
- 30 seconds
- Observation period (in vivo):
- 8 days
- Duration of post- treatment incubation (in vitro):
- no data available
- Number of animals or in vitro replicates:
- no data available
- Details on study design:
- REMOVAL OF TEST SUBSTANCE- Washing (if done): yes- Time after start of exposure: the treated eyes were washed with warm tap water 2 minutes after the 30 seconds exposure.
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 8 days
- Reversibility:
- not specified
- Remarks on result:
- positive indication of irritation
- Irritant / corrosive response data:
- Moderate pain response and discomfort was observed within 30 seconds of exposure. When the eyes were washed with warm tap water for 2 minutes after the 30 second exposure, the pain appeared to increase. All signs of eye irritation had resolved within 1 hour of treatment, but the conjunctiva remained inflames 8 days after exposure.
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritating to eyes) based on GHS criteria
- Conclusions:
- Moderate pain response and discomfort was observed within 30 seconds of exposure. When the eyes were washed with warm tap water for 2 minutes after the 30 second exposure, the pain appeared to increase. All signs of eye irritation had resolved within 1 hour of treatment, but the conjunctiva remained inflames 8 days after exposure.Hence, divinylbenzene can be considered to be irritating to eyes.
- Executive summary:
The eye irritation potential of divinylbenzene was assessed in rabbits.
0.1ml undiluted technical grade divinyl benzene was instilled into the eyes of 6 New Zealand White albino rabbits. The treated eyes were exposed to the test chemical for 30 seconds and washed with warm tap water 2 minutes after 30 seconds exposure.
Moderate pain response and discomfort was observed within 30 seconds of exposure. When the eyes were washed with warm tap water for 2 minutes after the 30 second exposure, the pain appeared to increase. All signs of eye irritation had resolved within 1 hour of treatment, but the conjunctiva remained inflames 8 days after exposure.
Hence,divinylbenzenecan be considered to be irritating to eyes.
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