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Physical & Chemical properties

Particle size distribution (Granulometry)

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Reference
Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Nov 2017 - Feb 2108
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
ISO 13320 (Particle size analysis - Laser diffraction methods)
Qualifier:
according to guideline
Guideline:
other: CIPAC MT 187 “Particle Size Analysis by Laser Diffraction”, Handbook K, 2007
GLP compliance:
yes
Type of method:
Laser scattering/diffraction
Type of particle tested:
primary particle
Type of distribution:
volumetric distribution
Mass median aerodynamic diameter:
ca. 5.802 µm
Geometric standard deviation:
ca. 0
Key result
Percentile:
D10
Mean:
ca. 1.461 µm
St. dev.:
0.3
Key result
Percentile:
D50
Mean:
ca. 5.802 µm
St. dev.:
0.3
Key result
Percentile:
D90
Mean:
ca. 35.079 µm
St. dev.:
2.8

Coefficient of variation for d50 is less than 3%; d10 and d90 are less than 5%. Thus repeatability of the characteristic particles in the size distribution are within the acceptable limits as per the ISO 13320-1 test standard.

Executive summary:

Full Test Results

RUN 1       RUN 2       RUN 3       RUN 4       RUN 5       Average**

Volume weighted mean        14.524       14.426        14.805        15.339      15.233        14.865

Median                                 5.805        5.777        5.793              5.822       5.815        5.802

Mode                                    5.326       5.327        5.322             5.325         5.331       5.326

MMAD *                             6.619       6.586          6.605             6.638          6.630        6.616

d10 - 10 % of material is <    1.461       1.455        1.459           1.466              1.465       1.461

d50 - 50 % of material is <   5.805       5.777        5.793              5.822            5.815       5.802

d90 - 90 % of material is <  35.430    33.538         34.527        36.272        35.754       35.079

All results are in μm

* Mass median aerodynamic diameter

** Average result is calculated from the entirety of data captured in each run and is not a simple arithmetic mean.

71.65 % by volume of sample was seen to be < 10.00 μm..

Description of key information

d10 - 10 % of material is          1.461

d50 - 50 % of material is          5.802

d90 - 90 % of material is         35.079

Additional information

Full Test Results

RUN 1       RUN 2       RUN 3       RUN 4       RUN 5       Average**

Volume weighted mean        14.524       14.426        14.805        15.339      15.233        14.865

Median                                 5.805        5.777        5.793              5.822       5.815        5.802

Mode                                    5.326       5.327        5.322             5.325         5.331       5.326

MMAD *                             6.619       6.586          6.605             6.638          6.630        6.616

d10 - 10 % of material is <    1.461       1.455        1.459           1.466              1.465       1.461

d50 - 50 % of material is <   5.805       5.777        5.793              5.822            5.815       5.802

d90 - 90 % of material is <  35.430    33.538         34.527        36.272        35.754       35.079

All results are in μm

* Mass median aerodynamic diameter

** Average result is calculated from the entirety of data captured in each run and is not a simple arithmetic mean.

71.65 % by volume of sample was seen to be < 10.00 μm..