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EC number: 221-904-3 | CAS number: 3275-24-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 201 (Alga, Growth Inhibition Test)
- Version / remarks:
- 1980
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- a 40% solution of dimethylamine in water was used for the test
supplied by Fluka, 99% purity - Analytical monitoring:
- not specified
- Vehicle:
- not specified
- Details on test solutions:
- no further information given
- Test organisms (species):
- Chlorella pyrenoidosa
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Hardness:
- culture medium used
hardness as CaCO3 = 90 - Test temperature:
- 20+-1°C
- pH:
- 8.7+-0.2 of culture medium
- Dissolved oxygen:
- no information
- Nominal and measured concentrations:
- nominal: 10, 18, 32, 56, 100, 180 mg/l
control - Details on test conditions:
- test solutions with an initial cell density of 10E-8 cells/litre (100ml) where added to 200 ml Erlenmeyer flask stoppered with a cotton plug and placed on a mechanical shaker under fluorescent light (7.5 W x m E-2). the cells were counted in a model ZbI Coulter Counter using a 70µm aperture. The test were carried out in triplicate
- Reference substance (positive control):
- not specified
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- 30 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- 22 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- cell number
- Reported statistics and error estimates:
- The EC50 values and their 95% confidence intervals were calculated according to Lichtfield and Wilkoxon (1949) method
Population growth curve were analysed according to Kooyman et al. 1983 - Validity criteria fulfilled:
- not specified
- Executive summary:
For dimethylamine an EC50 value of 30 mg/l (growth rate) were determined in a 96 h algae test equivalent or similar to OECD guideline 201.
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Data waiving:
- study technically not feasible
- Justification for data waiving:
- other:
- Justification for type of information:
- Titanium tetrakic(dimethylammonium) is an organometalic compound. It can only be handled air-free. It is a flammable liquid and very unstable (see also chapter 1.2 or 5.1.2 or 13). Within seconds it reacts violently in contact with moisture or water. Aquatic toxicity studies are technically not feasible. The decomposition products are dimethylamine and titanium oxide. Dimethylamine is a highly flammable gas. But dimethylamine is a well water soluble substance and was tested for acute aquatic toxicity.
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Qualifier:
- according to guideline
- Guideline:
- other: EPA guideline no further information was given
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- dimethylamine as 40% aqueous solution
- Analytical monitoring:
- yes
- Details on sampling:
- at the beginning of the test
frequently checking during the test
at the end of the test - Vehicle:
- no
- Test organisms (species):
- Selenastrum sp.
- Details on test organisms:
- Selenastrum capricornutum
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Remarks on exposure duration:
- 96 h was in accordance with the EPA guideline
- Post exposure observation period:
- yes until 7 days after
- Hardness:
- no information
- Test temperature:
- no information
- pH:
- no information
- Dissolved oxygen:
- no information
- Nominal and measured concentrations:
- nominal: 0; 1; 2, 5; 10; 20; 40; 80 mg/l
- Details on test conditions:
- Algae growth was evaluated by measuring in vivo the fluorimetric units at 48h; 72h; 96h and dafter 7 days
- Reference substance (positive control):
- not specified
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- 9 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Duration:
- 96 h
- Dose descriptor:
- EC0
- Effect conc.:
- 2 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Duration:
- 96 h
- Dose descriptor:
- EC100
- Effect conc.:
- 40 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Reported statistics and error estimates:
- The 96h EC50 was extrapolated from the eye fitted empirical curve on log-probability paper with percentages of growth inhibition and the logarithm of concentrations
- Validity criteria fulfilled:
- not specified
- Executive summary:
An EC50 after 96h exposure of 8mg/l was determined for dimethylamine. The test was carried out according to an EPA guideline.
Referenceopen allclose all
Description of key information
Titanium tetrakic(dimethylammonium) is an organometalic compound. It can only be handled air-free. It is a flammable liquid and very unstable (see also chapter 1.2 or 5.2.1 or 13). Within seconds it reacts violently in contact with moisture or water. Aquatic toxicity studies are technically not feasible. The decomposition products are dimethylamine and titanium oxide. Dimethylamine is a highly flammable gas. But dimethylamine is a well water soluble substance and was tested for acute aquatic toxicity. For dimethylamine an EC50 value of 30 mg/l (growth rate) were determined in a 96 h algae test equivalent or similar to OECD guideline 201 (van Leeuwen, 1985). In a second test (Calamari, 1980) an EC50 of 8mg/l after 96h exposure duration was determined for dimethylamine. The test was carried out according to an EPA guideline.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.