7-azatridecane-1,13-diamine

Endpoint summary

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

basic toxicokinetics

Type of information:

other: review of experimental results on primary and secondary aliphatic amines

Adequacy of study:

supporting study

Study period:

No data

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: Only secondary literature (evaluation and comparison of available data on alipathic amines)

Reason / purpose for cross-reference:

reference to same study

Conclusions:

After intravenous application of primary aliphatic amines, they were detected in the lung, liver, kidney, heart, spleen and brain. Metabolism found included oxidization via monoamine oxidase to aldehydes, followed by metabolic conversion to carboxylic acids via dehydration. Furthermore beta-oxidation was observed resulting in excretion of CO2. Monoamine oxidase selective binding was reduced with increasing chain length of the amines. Moreover the excretion via CO2 was found to be dependent on the chain lenght, too. Primary amines with C6 were shown to have the highest elimination rate via CO2. The rate diminishes with alterations in chain length (increasing as well as decreasing; <>>). Some amines are excreted mostly unmetabolised in the urine (e.g. ethylamine or diethylamin).

Reference 2

Endpoint:

dermal absorption

Type of information:

other: review of experimental results on primary and secondary aliphatic amines

Adequacy of study:

supporting study

Study period:

no data

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: Only secondary literature (evaluation and comparison of available data on alipathic amines)

Reason / purpose for cross-reference:

reference to same study

GLP compliance:

not specified

In general short chained amines (primary and secondary) are absorbed relatively well through the skin. Dermal absorption decreases with increasing chain length (i.e. >= C6).

Conclusions:

In general short chained amines (primary and secondary) are absorbed relatively well through the skin. Dermal absorption decreases with increasing chain length (i.e. >= C6).

Description of key information

There are no studies on toxicokinetic studies for the submission substance, which is a solid aliphatic triamine. There are two primary amine and one secondary amine functionalities within the substance.

General information regarding toxicokinetic behaviour are taken from a review on "Toxicity of aliphatic amines: structure-activity relationship".

After intravenous application of primary aliphatic amines, they were detected in the lung, liver, kidney, heart, spleen and brain. Metabolism found included oxidization via monoamine oxidase to aldehydes, followed by metabolic conversion to carboxylic acids via dehydration. Furthermore beta-oxidation was observed resulting in excretion of CO2. Monoamine oxidase selective binding was reduced with increasing chain length of the amines. Moreover the excretion via CO2 was found to be dependent on the chain length, too. Primary amines with C6 were shown to have the highest elimination rate via CO2. The rate diminishes with alterations in chain length (increasing as well as decreasing; <<C6>>>). Some amines are excreted mostly unmetabolised in the urine (e.g. ethylamine or diethylamine).

In general short chained amines (primary and secondary) are absorbed relatively well through the skin. Dermal absorption decreases with increasing chain length (i.e. >= C6).

Key value for chemical safety assessment

Bioaccumulation potential:

no bioaccumulation potential

Absorption rate - oral (%):

100

Absorption rate - dermal (%):

100

Absorption rate - inhalation (%):

100

Additional information

For further risk assessment the most conservative default assumptions were used for absorption via the different routes of exposure (100% absorption via each route).