Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 931-210-9 | CAS number: 1266534-73-9
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
NOEC(21d) = 32 mg/L (RA Zeolite cuboidal)
Key value for chemical safety assessment
Additional information
No data for long-term toxicity to aquatic invertebrates are available for the target substance Aluminium silicate and titanium oxide matrix doted with vanadium, nickel, and antimony. Therefore, data from the analogue approach source substance Zeolite, cuboidal, crystalline, synthetic, non-fibrous catalysts were applied to cover the endpoint long-term toxicity to aquatic invetebrates for the target substance.
The chronic toxicity study on Daphnia magna with Zeolite, cuboidal, crystalline, synthetic, non-fibrous, was conducted according to OECD 211 under GLP conditions (Paulus 2005, RL2). A saturated solution was prepared by shaking a nominal load of 1000 mg/L with deionised water for 24 hours, followed by membrane filtration (pore size not given). Then different dilutions of the filtered test solution were tested (10, 32, 100, 320 and 1000 mg/L). The mean offspring number was significant reduced at 100 mg/L and higher concentrations, mortality was observed in the two highest concentrations. Therefore, a NOEC(21d) = 32 mg/L was stated.
Generally, an indirect, physical effect of Zeolite, cuboidal, crystalline, synthetic, non-fibrous has to be assumed for daphnids: they are not able to distinguish food particles because of their nutritional quality (DeMott, 1986), in contrast to e.g. copepods or rotifers. Daphnids filter particles within a distinct size fraction defined by morphological parameters (Geller and Müller, 1981; Gophen and Geller, 1984), which is 1 to 100 µm for Daphnia magna. Zeolite, cuboidal, crystalline, synthetic, non-fibrous with an aggregate size within a range of about 1 to 20 µm is therefore exactly within this size spectrum, implying that daphnids may mainly ingest cuboidal Zeolite in turbid suspensions or will delete the complete filtered particles with their furca claw prior to ingestion and starve.
Therfore it can be presumed, that the above described effect is due to physical effects. Up to the limit of water solubility, no effects could be observed.
A further study with Zeolite, cuboidal, crystalline, synthetic, non-fibrous was available (not shown here), which supported the results from the discussed key study.
Additional data for long-term toxicity to aquatic invertebrates are available for the following source substance which serve as potential data source for the analogue approach of Aluminium silicate and titanium oxide matrix doted with vanadium, nickel, and antimony:
- Source chemical 6 - Kaolin:
NOEC(30 d) = 100 mg/L, Oncorhynchus mykiss; Hashimoto et al. 1986
In accordance with the target substance, the available data for this source substance also provide a low potential for long-term toxicity to aquatic invertebrates.
The respective references for the source substance data can be found in the data matrix of the justification for the analogue approach, which can be found either in the CSR or as attachment in Iuclid section 13.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
