Decyl laurate

Short-term toxicity to fish

Link to relevant study record(s)

Reference

Endpoint:

short-term toxicity to fish

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Justification for type of information:

Please refer to the analogue approach justification provided in IUCLID section 13.

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

read-across source

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

> 100 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Remarks on result:

other:

Remarks:

Source: CAS 3234-85-3, Evonik, 2012, D. rerio, 96 h

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

> 0.189 µg/L

Nominal / measured:

meas. (initial)

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Remarks on result:

other:

Remarks:

Source: CAS 3234-85-3, Evonik, 2012, D. rerio, 96 h

Conclusions:

The retained effect value for short-term toxicity of the target substance to fish is an LC50 (96 h) of > 0.189 µg/L (meas. initial), corresponding to > 100 mg/L (nominal), based on the results of a GLP-guideline study with a closely related source substance (OECD 203, CAS 3234-85-3); read-across

Description of key information

No effects up to the limit of water solubility (OECD 203, D. rerio); read-across

Additional information

There is no study available, in which the short-term toxicity of decyl laurate (CAS 36528-28-6) to fish was assessed according to OECD guidelines and GLP. Therefore, read-across to the structurally related source substances tetradecyl myristate (CAS 3234-85-3) and fatty acids, C8-10, C12-18-alkyl esters (CAS 95912-86-0) was performed in accordance with Regulation (EC) No 1907/2006 Annex XI, 1.5. The source substances are characterized by similar fatty acid chain lengths as well as alcohol components and are therefore considered suitable representatives for the assessment of the acute toxicity of the target substance to fish. A detailed read-across justification is provided in the analogue justification in IUCLID section 13.

Both available studies were performed according to OECD guideline 203 and GLP.

In the study with the source substance tetradecyl myristate (CAS 3234-85-3) a static limit test was performed, in which Danio rerio was exposed to a water accommodated fraction with a nominal concentration of 100 mg/L test item for 96 h. The test item concentration was analytically verified by GC/EI-MS at the start and end of the test.

The measured test item concentrations were of ≤0.01% of nominal (0.189 µg/L) at the start and < LOQ (0.1 µg/L) at the end of the test, respectively. After 96 h of incubation, no mortality was observed, resulting in an LL50 of > 0.189 µg/L (measured initial concentration) and of > 100 mg/L (nominal), respectively. Based on this result it can be concluded that the test item does not cause short-term toxic effects to fish up to the limit of water solubility.

In the study with the source substance fatty acids, C8-10, C12-18-alky esters (CAS 95912-86-0) a semi-static limit test was conducted, in which Danio rerio was exposed to a water accommodated fraction with a nominal concentration of 100 mg/L test item for 96 h.

After 96 h no mortality was observed, resulting in an LL50 (96 h) > 100 mg/L (nominal) and a NOELR (96 h) ≥ 100 mg/L (nominal). Based on the result it can be concluded that the test item does not cause short-term toxic effects to fish up to the limit of water solubility.

Based on the structural and chemical similarity of the target and source substances, the target substance is expected to exhibit a similar ecotoxicological profile. Therefore, it can be concluded that the target substance decyl laurate (CAS 36528 -28-6) does not cause short-term toxic effects to fish up to the limit of water solubility.