Decyl laurate

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

key study

Study period:

18 Dec - 23 Dec 1995

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study with acceptable restrictions

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1996

Report date:

1996

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 404 (Acute Dermal Irritation / Corrosion)

Deviations:

yes

Remarks:

only basic data given, test substance purity not specified

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

2-ethylhexyl laurate

EC Number:

243-697-9

EC Name:

2-ethylhexyl laurate

Cas Number:

20292-08-4

Molecular formula:

C20H40O2

IUPAC Name:

2-ethylhexyl laurate

Test animals

Species:

rabbit

Strain:

other: New Zealand

Test system

Type of coverage:

not specified

Preparation of test site:

not specified

Vehicle:

not specified

Controls:

not required

Duration of treatment / exposure:

single application

Observation period:

Reading time points: 1, 24, 48 and 72 h
7 days

Number of animals:

3

Details on study design:

SCORING SYSTEM: Draize scoring system

Results and discussion

In vivo

Results

Results 1

Irritation parameter:

erythema score

Basis:

animal #1

Time point:

24/48/72 h

Score:

1

Max. score:

4

Reversibility:

fully reversible within: 72 hours

Results 2

Irritation parameter:

erythema score

Basis:

animal #2

Time point:

24/48/72 h

Score:

1.33

Max. score:

4

Reversibility:

fully reversible within: 72 hours

Results 3

Irritation parameter:

erythema score

Basis:

animal #3

Time point:

24/48/72 h

Score:

2

Max. score:

4

Reversibility:

fully reversible within: 7 days

Results 4

Irritation parameter:

edema score

Basis:

mean

Remarks:

out of all 3 animals

Time point:

24/48/72 h

Score:

0

Max. score:

4

Reversibility:

other: reversibility not applicable

Irritant / corrosive response data:

Desquamative reaction, with moderated cutaneous extensive range index for 3 animals from Day 4 to Day 7 was observed.

Any other information on results incl. tables

Table 1: Results of skin irritation study

Observation time	Animal no.
	1		2		3
	Erythema	Edema	Erythema	Edema	Erythema	Edema
1 h	0	0	0	0	1	0
24 h	2	0	2	0	2	0
48 h	1	0	2	0	2	0
72 h	0	0	0	0	2	0
7 d	0	0	0	0	0	0
Mean value 24 + 48 + 72 h	1.0	0	1.33	0	2.0	0

Applicant's summary and conclusion

Interpretation of results:

other: CLP/EU GHS criteria not met, no classification required according to Regulation (EC) No 1272/2008.