Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 687-634-7 | CAS number: 231937-89-6
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- May 5, 2006 - October 19, 2006
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 006
- Report date:
- 2006
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
Test material
- Reference substance name:
- 2-methyl-4-oxo-3-(prop-2-en-1-yl)cyclopent-2-en-1-yl (1R)-2,2-dimethyl-3-(2-methylprop-1-en-1-yl)cyclopropane-1-carboxylate
- EC Number:
- 687-634-7
- Cas Number:
- 231937-89-6
- Molecular formula:
- C19H26O3
- IUPAC Name:
- 2-methyl-4-oxo-3-(prop-2-en-1-yl)cyclopent-2-en-1-yl (1R)-2,2-dimethyl-3-(2-methylprop-1-en-1-yl)cyclopropane-1-carboxylate
- Test material form:
- liquid: viscous
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: 80% glycol in water
- Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- 5,767 mg/L
- No. of animals per sex per dose:
- 5 male, 5 female
- Control animals:
- yes
- Remarks:
- 5 male, 5 female
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LC50
- Effect level:
- > 5.767 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Mortality:
- 10 %
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- 10% mortality occurred at the maximum achievable breathing zone concentration. The acute inhalation median lethal concentration of the test material was concluded to be greater than 5.767 mg/L.
However, based on the IPCS evaluation of allethrins (EHC 87, 1989), the inhalation toxicity values (LC50 values) were found to be > 1500 mg/m3 (in the mouse and rat), hence the self-classification is considered as Acute Tox. 4; H332. - Executive summary:
Two groups of rats were used for the study. Group I was exposed to glycol in water and serves as control group, while group II was exposed to the maximum achievable concentration of d-Allethrin in the glycol water solution. Rats from both groups were exposed for 4 hours followed by a 14 days observation period.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
